- Method for preparing diethyl malonate
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The invention relates to a novel method for preparing diethyl malonate, comprisign the following steps: using malonate as a raw material, sodium hydride as a catalyst and diethyl sulfate as an ethylation reagent, stirring at 70-100 DEG C to react for 3-5 hours, and carrying out after-treatment on the reaction solution after the reaction is finished. The method is low in cost, easy in reaction operation and high in yield.
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Paragraph 0011-0013
(2020/06/02)
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- COMPOUNDS AND USES
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The invention relates to novel compounds (I), the use of compounds in eliciting a pro-Th17 immune response and related aspects. Further provided are methods of production of said compounds (I).
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Page/Page column 21
(2019/11/04)
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- Copper(II)-catalyzed enantioselective intramolecular cyclization of N-alkenylureas
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The first Cu(II)-catalyzed highly enantioselective intramolecular cyclization of N-alkenylureas was developed for the concise assembly of chiral vicinal diamino bicyclic heterocycles. Facile removal of carbonyl group of the carbamido moiety allowed for ready access to enantioenriched cyclic vicinal diamines.
- Fu, Shaomin,Yang, Honghao,Deng, Yuanfu,Jiang, Huanfeng,Zeng, Wei,Li, Guoqiang
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supporting information
p. 1018 - 1021
(2015/03/30)
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- Alkylation of Monosubstituted Malonate Anions With Pyridinium and Quinolinium Salts
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Monosubstituted malonate anions are alkylated at room temperature with 1-(sec-alkyl)quinolinium salts.Hindered disubstituted malonate esters can thus be prepared under very mild conditions.
- Katritzky, Alan R.,Aurrecoechea, Jose M.
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p. 342 - 345
(2007/10/02)
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- ALKYLATION OF MALONIC ESTER AND MONOALKYLMALONIC ESTERS UNDER THE CONDITIONS OF PHASE-TRANSFER CATALYSIS
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Simple procedures were developed for the monoalkylation of malonic ester in the potassium hydroxide-DMFA (DMFA-acetone)-triethylbenzylammonium chloride system and the alkylation of alkylmalonic esters to dialkylmalonic esters in the calcium oxide-DMFA system.
- Sukhanov, N. N.,Trappel', L. N.,Chetverikov, V. P.,Yanovskaya, L. A.
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p. 2288 - 2290
(2007/10/02)
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- ASSIGNMENT OF THE DEUTERIUM QUADRUPOLAR SPLITTINGS FOR THE END-CHAIN OF 4-CYANO-4 prime -OCTYLBIPHENYL IN THE NEMATIC PHASE: A TEST BETWEEN THEORETICAL MODELS FOR END-CHAIN CONFORMATIONAL MOTION AND ORIENTATIONAL ORDERING.
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4-Cyano-4 prime -(1,1,5,5-d//4-octyl)-biphenyl and 4-cyano-4 prime -(1,1,6,6-d//4-octyl)-biphenyl were synthesized and the deuterium quadrupole splittings measured for 4-octyl)-binphenyl nematic phases. The results, when combined with previous measurements on other specifically deuteriated derivatives enable a virtually complete assignment to be made of the quadrupolar splittings in the deuterium nmr spectrum of the perdeuteriated end-chain of this mesogen.
- Boden,Bushby,Clark
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p. 179 - 135
(2007/10/02)
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