- PROTEIN STERILISATION BY RADIATION AND ADDITION OF A STABILISING COMPOSITION
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A method of sterilising a protein, comprises exposing to ionising radiation an at least substantially dry composition comprises a protein and a protective compound or combination of protective compounds having both of the following characteristics: (i) a rate of reaction with singlet oxygen greater than 1×10 7 L mol?1 S?1; (ii) being a reducing agent whilst at the same time containing a proton dissociable group with a pKa no more than 3 units from the pH of the composition. The compound having characteristic (i) is selected from histidine, thiamine and tryptophan, the compound having characteristic (ii) is selected from methionine, malate, citrate, lactate and tiron. The radiation is gamma radiation or electron beam, whereby the preferred dose is 15-40 kGy.
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- Treatment of genitourinary tract disorders
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Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.
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- Oil-in-water emulsion and process for producing the same
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The invention relates to an oil-in-water emulsion obtained by mixing (a) a polymer compound having, in a side chain, a group represented by formula (1):-(OX)n-E2-R wherein X represents a C1 to C6 divalent saturated hydrocarbon group, n is a number of 5 to 300, E2 is an ether linkage or an ester linkage, and R represents a C4 to C30 hydrocarbon group, (b) a water-soluble polyol, (c) a nonionic surfactant, (d) a hydrophobic compound, and water and diluting the resulting mixture with water and a process for producing the same.
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Page/Page column 9
(2008/06/13)
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- Process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone
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The present invention relates to a process for preparing optically pure (S)-3-hydroxy-γ-butyrolactone expressed by the following Formula 1 and more particularly, to a process that enables preparing optically pure (S)-3-hydroxy-γ-butyrolactone economically in large quantities, by: (a) Preparing α-(1,4) linked oligosaccharide with adequate sugar distribution by reacting starch which is easily available from natural product with enzyme under a specific condition; and (b) Performing oxidation and cyclization sequentially under a specific condition.
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- Treatment of genitourinary tract disorders
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Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.
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- Fibrinogen-coated particles for therapeutic use
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The invention provides a particle comprising fibrinogen bound on the surface of an albumin matrix, wherein said particle is capable of coaggregation with platelet, and of aggregation in a solution containing soluble fibrinogen at a concentration of soluble fibrinogen not capable by it self of formation of a clot upon activation by thrombin.
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- Antipsychotic sulfonamide-heterocycles, and methods of use thereof
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One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds comprising a sulfonamide moiety to treat diseases, afflictions or maladies caused at least in part by abnormal activity of one or more GPCRs or ligand-gated ion channels. An additional aspect of the present invention relates to the synthesis of combinatorial libraries of the heterocyclic compounds comprising a sulfonamide moiety, and the screening of those libraries for biological activity, e.g., in animal models of psychosis.
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- Method for eliminating Staphylococcus aureus, novel microorganism of genus Brachybacterium, and care garment, care sheet or care bedclothes, each being immobilized with microorganism of genus Brachybacterium
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A method for eliminating Staphylococcus aureus is disclosed, including inoculating a microorganism of the genus Brachybacterium to Staphylococcus aureus to eliminate Staphylococcus aureus. A care garment, a care sheet or care bedclothes, each being immobilized with a microorganism or genus Brachybacterium, is also disclosed. One of the microorganismns of the genus Brachybacterium useful in the invention is novel and is deposited as a bacterial strain AAA-a of the genus Brachybacterium (Accession No. FERM BP-6848) in the International Depositary Authority for the deposit of microorganism.
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- Cyclodextrin derivatives having at least one nitrogen-containing heterocycle, their preparation and use
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Reactive cyclodextrin derivatives have at least one nitrogen-containing heterocycle. The reactive cyclodextrin derivatives include at least one nitrogen-containing heterocycle having at least one electrophilic center.
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- Process for the protection of plant seeds and apparatus to carry out said process
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An improved process for the phytoprotection of plant seeds, wherein there is simultaneously applied to the seeds, on the one hand, at least one first liquid composition containing at least one phytoprotection product, and on the other hand, a foam formed from a second composition, containing at least one nonphytotoxic foaming agent.
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- Galenical formulation of toloxatone
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A new formulation for the oral administration of Toloxatone, an anti-depressant, contains 400 to 600 mg of Toloxatone per unit dose. Such a high Toloxatone content is possible due to the discovery that Toloxatone is competitive with Tyramine towards the A form of a monomine oxidase, and thus does not cause hypertensive crisis. The anti-depressant composition of this invention can therefore be administered to the patient even when Tyramine is present in the patient's system.
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- 6-Azaoligocycloalkylmethyleneaminopenam compounds
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6-Amino-penam compounds, having an antimicrobial action, of the formula STR1 in which R1 is an azaoligocycloalkyl radical which is bonded via the ring nitrogen atom and contains at least one endo-bridge atom and a total of 7 to 12 ring atoms and can contain a double bond and/or, if desired, as a further ring hetero-atom, an oxygen atom, or a nitrogen atom which can link the radical X1, where X1 is hydrogen or lower alkyl, and/or, if desired, free, esterified or etherified hydroxyl which is bonded to a ring carbon atom, and in which R2 is free carboxyl or carboxyl esterified by a physiologically detachable group, and salts of such compounds, processes for their preparation, pharmaceutical preparations which contain these compounds, including mixtures of these compounds with other antimicrobial, especially antibacterial and/or antiviral, active ingredients and/or additional substances or substance mixtures which alleviate the symptoms in the case of infections, the use of the novel compounds of the formula I and their salts, and of the novel substance mixtures, for combating micro-organisms and the preparation of corresponding medicaments by non-chemical means.
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- Fungicidal carbamates of triazole ethanols (or ethenols)
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2-(Methoxycarbonylamino)-1H-benzimidazole-1-carboxylic acid esters such as with 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol are effective in controlling plant fungus diseases.
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