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Cas Database

106-31-0

106-31-0

Identification

  • Product Name:Butanoic acid,1,1'-anhydride

  • CAS Number: 106-31-0

  • EINECS:203-383-4

  • Molecular Weight:158.197

  • Molecular Formula: C8H14O3

  • HS Code:2915.90

  • Mol File:106-31-0.mol

Synonyms:Butanoicacid, anhydride (9CI);Butyric anhydride (6CI,8CI);Butanoic anhydride;Butanoyl anhydride;Butyric acid anhydride;Butyryl oxide;n-Butyric acidanhydride;n-Butyric anhydride;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes: C:Corrosive;

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH314 Causes severe skin burns and eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016) Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Organic acids and related compounds/

  • Fire-fighting measures: Suitable extinguishing media Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. Use water spray to knock-down vapors. Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:Butyric anhydride
  • Packaging:250ml
  • Price:$ 165
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Butyric Anhydride >98.0%(T)
  • Packaging:500mL
  • Price:$ 136
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Butyric Anhydride >98.0%(T)
  • Packaging:25mL
  • Price:$ 26
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride 98%
  • Packaging:1 SAMPLE
  • Price:$ 50
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride 98%
  • Packaging:sample
  • Price:$ 50
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride 98%
  • Packaging:1kg
  • Price:$ 88
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride for synthesis. CAS No. 106-31-0, EC Number 203-383-4., for synthesis
  • Packaging:8005031000
  • Price:$ 81.9
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride for synthesis
  • Packaging:1 L
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride 98%
  • Packaging:1l
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Butyric anhydride purum, ≥97.0% (NT)
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Relevant articles and documentsAll total 21 Articles be found

-

Tolmacheva,G.M. et al.

, (1979)

-

-

Kuwajima,Mukaiyama

, p. 1385 (1964)

-

Cobalt(II)-Catalyzed Reaction of Enolizable Aldehydes with Alkenes in the Presence of Dioxygen: The Role of Acyl Radical

Punniyamurthy, T.,Bhatia, Beena,Iqbal, Javed

, p. 850 - 853 (1994)

Complex cobalt(II) (1) catalyzes the reaction of enolizable aliphatic aldehydes and dioxygen with an electron-deficient alkene to afford the adducts 4 and 5, whereas the reaction with unactivated alkenes leads to the corresponding epoxides 6.These reactions are proposed to proceed via a common pathway involving acyl radicals.

REACTION OF PHOSPHORUS TRICHLORIDE WITH CARBOXYLIC ACIDS

Valitova, L. A.,Popova, E. V.,Ibragimov, Sh. N.,Ivanov, B. E.

, p. 366 - 370 (1990)

The reaction of phosphorus trichloride with a number of monobasic carboxylic acids has been studied and the optimum ratio of reactants for the yield of acid chlorides has been established.Based on analysis and the data from 31P NMR spectroscopy of the phosphorus-containing products from this reaction it is shown that at 40-50 deg C a mixture of P-H acids having a predominant content of pyrophosphorous acid is formed.

Effects of a forming process on the properties and structure of RANEY-Ni catalysts for the hydrogenation of 1,4-butenediol

Fan, Xing,Gao, Xianlong,Ma, Fengyun,Mo, Wenlong,Noritatsu, Tsubaki,Wu, Hongli

, p. 5516 - 5524 (2020)

Three commercial Ni-Al alloys formed by a vacuum atomization method (NAV), atmospheric atomization method (NAA) and high-temperature melting method (NAH) were leached by 10 wt% NaOH solution to prepare three RANEY-Ni catalysts (RNAV, RNAA and RNAH, correspondingly). The effects of a forming process on the structure of Ni-Al alloys and the corresponding RANEY-Ni catalysts were investigated via XRD, XPS, SEM, TEM, NH3-TPD, N2 adsorption-desorption and EDX-mapping studies. Also, the as-prepared RANEY-Ni catalysts were evaluated via the hydrogenation of 1,4-butenediol (BED) to produce 1,4-butanediol (BDO). The results showed that the specific surface areas and surface morphologies of the Ni-Al alloys present significant differences. Meanwhile, the RNAA sample presented a comparatively regular morphology, similar to a small piece of sugar cane. The weak and medium acid peak areas of the RNAA catalyst were lower than those of the other samples. RNAV showed higher weak and medium acid peak areas, demonstrating the higher number of acid centers on the surface of the catalyst. The surface of the RNAA catalyst obtained from NAA contained more active component-Ni, about 90 wt% on the surface, and the specific surface area of the sample was 75 times that of its precursor Ni-Al alloy powder (NAA). The evaluation results present that the RNAA catalyst shows better hydrogenation performance, with BED conversion of 100%, both BDO selectivity and yield of 46.11%.

Development of triazine-based esterifying reagents containing pyridines as a nucleophilic catalyst

Yamada, Kohei,Liu, Jie,Kunishima, Munetaka

supporting information, p. 6569 - 6575 (2018/09/25)

We have developed new triazine-based esterifying reagents comprising pyridines that can act as a nucleophilic catalyst. 1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-3,5-lutidinium chloride (DMT-3,5-LUT) was found to exhibit a superior reactivity for the dehydrating condensation reaction between carboxylic acids and alcohols. The reaction of DMT-3,5-LUT with carboxylic acids produces intermediacy of acyloxytriazines, which is known to exhibit moderate reactivity toward alcohols, with concomitant liberation of 3,5-lutidine. The subsequent chemical transformation of the acyloxytriazines and alcohols into esters can be accelerated by the action of 3,5-lutidine as a nucleophilic catalyst. The detailed reaction mechanism revealed by a time-course analysis of the reactions is also discussed.

Study on 1,3,5-triazine chemistry in dehydrocondensation: Gauche effect on the generation of active triazinylammonium species

Kunishima, Munetaka,Ujigawa, Takae,Nagaoka, Yoshie,Kawachi, Chiho,Hioki, Kazuhito,Shiro, Motoo

, p. 15856 - 15867 (2013/01/16)

The reaction of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) with various nitrogen-containing compounds, particularly tertiary amines (tert-amines), has been studied for the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl) trialkylammonium salts [DMT-Am(s)]. DMT-Ams derived from aliphatic tert-amines exhibited activity for the dehydrocondensation between a carboxylic acid and an amine to form an amide in a model reaction. Based on a conformational analysis of DMT-Ams and tert-amines by NMR and X-ray diffraction methods, we concluded that a β-alkyl group maintained in a gauche relationship with the nitrogen lone pair of tert-amines significantly hinders the approach of CDMT to the nitrogen. Thus, trimethylamine and quinuclidine without such alkyl groups readily react with CDMT whereas triethylamine, possessing two or three such gauche β-alkyl groups in the stable conformations, does not react at all. The theory of "gauche β-alkyl group effect" proposed here provides useful guidelines for the preparation of DMT-Ams possessing various tertiary amine moieties. An investigation of the dehydrocondensation activity of tert-amines in a CDMT/tert-amine system that involves in situ generation of DMT-Am, showed that the gauche effect of the β-alkyl group becomes quite pronounced; the yield of the amide decreases significantly with tert-amines possessing an unavoidable gauche β-alkyl group. Thus, the tert-amine/CDMT systems are useful for judging whether tert-amines can readily react with CDMT without isolation of DMT-Ams. The right approach! The structure-activity relationship of nitrogen-containing compounds including aliphatic tertiary amines in the reaction with 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) has been investigated (see scheme). The theory of "gauche β-alkyl group effect" proposed here provides useful guidelines for the preparation of triazine-based dehydrocondensation reagents (DMT-Ams) possessing various tertiary amine moieties. Copyright

Efficient and convenient synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by phase transfer catalysis

Hu, Yu Lin,Zhao, Xing E.,Lu, Ming

experimental part, p. 255 - 262 (2012/04/17)

An efficient and convenient procedure for the synthesis of symmetrical carboxylic anhydrides from carboxylic acids with sulfated zirconia by PEG-1000 phase transfer catalysis has been developed. The reactions proceeded under mild and solvent-free conditions to provide the carboxylic anhydrides in good to excellent yields. The product can be isolated by a simple extraction with organic solvent, and the catalyst system can be recycled or reused without any significant loss of catalytic activity.

CASPASE INHIBITORS AND USES THEREOF

-

Page/Page column 27, (2010/04/03)

This invention provides novel caspase inhibitors useful for prophylaxis or treatment of a number of pathologies, including, for example, Huntington's disease. In certain embodiments the inhibitors include inhibitors of casepase-3 and/or casepase-6.

Process route upstream and downstream products

Process route

butyric acid silicic acid-anhydride
994-52-5

butyric acid silicic acid-anhydride

butanoic acid anhydride
106-31-0

butanoic acid anhydride

propiophenone
495-40-9

propiophenone

Conditions
Conditions Yield
With aluminium trichloride; benzene;
With benzene; AlCl3;
butyric acid silicic acid-anhydride
994-52-5

butyric acid silicic acid-anhydride

butanoic acid anhydride
106-31-0

butanoic acid anhydride

1-(4-methylphenyl)butan-1-one
4160-52-5

1-(4-methylphenyl)butan-1-one

Conditions
Conditions Yield
With aluminium trichloride;
With AlCl3;
aluminium trichloride
7446-70-0

aluminium trichloride

butyric acid silicic acid-anhydride
994-52-5

butyric acid silicic acid-anhydride

butanoic acid anhydride
106-31-0

butanoic acid anhydride

propiophenone
495-40-9

propiophenone

butyric acid
107-92-6

butyric acid

Conditions
Conditions Yield
reagiert analog mit Toluol;
(dibutyrylhydroxy)triphenylarsorane
125911-01-5

(dibutyrylhydroxy)triphenylarsorane

butanoic acid anhydride
106-31-0

butanoic acid anhydride

triphenyl-arsane
603-32-7

triphenyl-arsane

triphenylarsineoxide
1153-05-5,856568-31-5

triphenylarsineoxide

Conditions
Conditions Yield
Product distribution; Heating;
76%
38%
43%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

Butane-1,4-diol
110-63-4

Butane-1,4-diol

1-octen-3-ol
3391-86-4

1-octen-3-ol

Conditions
Conditions Yield
With hydrogen; In water; at 119.84 ℃; for 3h; under 37503.8 Torr; Reagent/catalyst;
butanoic acid methyl ester
623-42-7

butanoic acid methyl ester

acetic anhydride
108-24-7

acetic anhydride

butanoic acid anhydride
106-31-0

butanoic acid anhydride

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
Conditions Yield
With sulfuric acid;
ethynyl methyl ether
6443-91-0

ethynyl methyl ether

butyric acid
107-92-6

butyric acid

butanoic acid anhydride
106-31-0

butanoic acid anhydride

acetic acid methyl ester
79-20-9

acetic acid methyl ester

Conditions
Conditions Yield
analoge Reaktionen mit weiteren Saeuren;
butyraldehyde
123-72-8

butyraldehyde

acrylic acid methyl ester
292638-85-8,9003-21-8,96-33-3

acrylic acid methyl ester

butanoic acid anhydride
106-31-0

butanoic acid anhydride

Methyl 2-hydroxy-4-oxoheptanoate

Methyl 2-hydroxy-4-oxoheptanoate

Methyl 2-butyryloxy-4-oxoheptanoate

Methyl 2-butyryloxy-4-oxoheptanoate

butyric acid
107-92-6

butyric acid

Conditions
Conditions Yield
With acetic anhydride; cobalt(II); In acetonitrile; at 25 ℃; for 24h;
18%
20%
4-Octyne
1942-45-6

4-Octyne

butanoic acid anhydride
106-31-0

butanoic acid anhydride

octane-4,5-dione
5455-24-3

octane-4,5-dione

butyric acid
107-92-6

butyric acid

Conditions
Conditions Yield
With ruthenium(IV) oxide; Oxone; sodium hydrogencarbonate; In water; ethyl acetate; acetonitrile; at 20 ℃; for 0.333333h; Title compound not separated from byproducts;
2-phenylethanol
60-12-8

2-phenylethanol

butyric acid
107-92-6

butyric acid

butanoic acid anhydride
106-31-0

butanoic acid anhydride

phenethyl butyrate
103-52-6

phenethyl butyrate

Conditions
Conditions Yield
With 4-methyl-morpholine; 1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-3,5-dimethylpyridin-1-ium chloride; In chloroform-d1; at 23 ℃; for 0.166667h; Reagent/catalyst;
37 %Spectr.
58 %Spectr.

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