1445-45-0

Basic information

• Product Name: Trimethyl orthoacetate
• Synonyms: 1,1,1-trimethoxy-ethan;CH3C(OCH3)3;Methyl orthoacetate;trimethyl-acetate;Trimethylorthoaceate;ORTHOACETIC ACID TRIMETHYL ESTER;TMOA;TRIMETHYL ORTHOACETATE
• CAS NO: 1445-45-0
• Molecular Formula: C₅H₁₂O₃
• Molecular Weight: 120.15
• EINECS: 215-892-9
• Product Categories: Orthoesters;Acetals/Ketals/Ortho Esters;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Organic synthesis
• Mol File: 1445-45-0.mol

Chemical Properties

• Boiling Point: 107-109 °C(lit.)
• Flash Point: 62 °F
• Appearance: Clear colorless to slightly brown/Liquid
• Density: 0.944 g/mL at 25 °C(lit.)
• Vapor Pressure: 6.25mmHg at 25°C
• Refractive Index: n20/D 1.388(lit.)
• Storage Temp.: Flammables area
• Water Solubility: HYDROLYSIS
• Sensitive: Moisture Sensitive
• BRN: 1098338
• CAS DataBase Reference: Trimethyl orthoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Trimethyl orthoacetate(1445-45-0)
• EPA Substance Registry System: Trimethyl orthoacetate(1445-45-0)

Safety Data

• Hazard Codes: F,Xi
• Statements: 11-43-38-36/37/38
• Safety Statements: 16-37/39-24-33-26-7/9
• RIDADR: UN 3272 3/PG 2
• WGK Germany: 1
• TSCA: Yes
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 1445-45-0(Hazardous Substances Data)

Usage

Uses

1. Pharmaceutical Industry:
Trimethyl orthoacetate is used as an intermediate in the synthesis of various pharmaceutical compounds, specifically for the preparation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyl-oxymethyl-4-alkoxycarbonyloxybut-1-yl)purines. These compounds have potential applications in the development of new drugs and therapies.
2. Chemical Research:
In the field of chemical research, trimethyl orthoacetate serves as a subject for studying the kinetics and mechanism of gas-phase elimination reactions. This helps in understanding the behavior of the compound under different temperature and pressure conditions, which can be useful for optimizing reaction conditions and improving the efficiency of related chemical processes.
3. Organic Synthesis:
Trimethyl orthoacetate can be used as a reagent in organic synthesis, particularly for the preparation of various organic compounds with potential applications in different industries, such as pharmaceuticals, agrochemicals, and materials science.

InChI:InChI：1S/C5H12O3/c1-5(6-2,7-3)8-4/h1-4H3

Synthetic route

methanol (67-56-1) + acetonitrile (75-05-8) → Trimethyl orthoacetate (1445-45-0)

Conditions	Yield
Stage #1: methanol; acetonitrile With hydrogenchloride; cetyltrimethylammonium chloride In hexane at -10℃; for 6h; Large scale; Stage #2: methanol at 40℃; for 4h; pH=5-6; Reagent/catalyst; Temperature; Large scale;	95.16%
Stage #1: methanol; acetonitrile With hydrogenchloride In 1,3,5-trimethyl-benzene at 0 - 25℃; for 8h; Large scale; Stage #2: With ammonia at 0 - 39℃; for 8h; pH=5 - 6; Solvent; Large scale;	87%
Stage #1: methanol; acetonitrile With hydrogenchloride In 1,3,5-trimethyl-benzene at 0 - 25℃; Large scale; Stage #2: With ammonia at 37 - 39℃; for 8h; pH=5-6; Solvent; Large scale;	87%

methanol (67-56-1) + methyl acetimidate hydrochloride (14777-27-6) → Trimethyl orthoacetate (1445-45-0)

Conditions	Yield
With ammonia at 0 - 40℃; pH=5.6;	80%

methanol (67-56-1) + 1,1-dichloro-1-nitroethane (594-72-9) + sodium methylate (124-41-4) → Trimethyl orthoacetate (1445-45-0)

Conditions	Yield
Irradiation;	56%

1,1-dimethoxyethylene (922-69-0) + acetaldehyde (75-07-0) → Trimethyl orthoacetate (1445-45-0) + trans-Crotonaldehyde (123-73-9) + crotonic acid methyl ester (623-43-8) + acetic acid methyl ester (79-20-9)

Conditions	Yield
at 150℃;

methanol (67-56-1) + diethyl ether (60-29-7) + 1-((2-chloroethyl)oxy)ethanimine hydrochloride (82190-86-1) → Trimethyl orthoacetate (1445-45-0) + 1,1-divinyloxy-1-methoxyethane (82190-84-9)

Conditions	Yield
With potassium tert-butylate Yield given. Yields of byproduct given;

methanol (67-56-1) + acetic acid methyl ester (79-20-9) → Trimethyl orthoacetate (1445-45-0)

Conditions	Yield
With triethylamine at 37℃; Irradiation; gas phase alcoholysis; Yield given;

Trimethyl orthoacetate (1445-45-0) + diethyl (2R,3R)-tartrate (87-91-2) → diethyl (4R)-trans-2-methoxy-2-methyl-1,3-dioxolan-4,5-dicarboxylate (134745-01-0)

Conditions	Yield
With toluene-4-sulfonic acid In dichloromethane at 20℃; for 12h;	100%
With sulfuric acid In benzene at 80℃;	98%

Trimethyl orthoacetate (1445-45-0) + tris(trimethylsilyloxy)ethylene (69097-20-7) → 3,3-Dimethoxy-2-(trimethylsiloxy)butansaeure-trimethylsilylester (108009-58-1)

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate In dichloromethane at 0℃; for 16h;	100%

Trimethyl orthoacetate (1445-45-0) + (2R,3S)-methyl 2,3-dihydroxy-3-(4-methoxyphenyl)propanoate (122517-81-1) → (4R,5S)-2-Methoxy-5-(4-methoxy-phenyl)-2-methyl-[1,3]dioxolane-4-carboxylic acid methyl ester (106146-95-6)

Conditions	Yield
With toluene-4-sulfonic acid	100%

Trimethyl orthoacetate (1445-45-0) + 4-methoxy-2-(trimethylsilyloxy)furan (82204-15-7) → methyl 5-(1,1-dimethoxyethyl)tetronate (82204-19-1)

Conditions	Yield
With titanium tetrachloride In dichloromethane -95 deg C, 1 h, RT., 2 days;	100%

Trimethyl orthoacetate (1445-45-0) + allyl 4-O-benzyl-α-L-rhamnopyranoside (89821-78-3) → allyl 2-O-acetyl-4-O-benzyl-α-L-rhamnopyranoside (134136-22-4)

Conditions	Yield
Stage #1: Trimethyl orthoacetate; allyl 4-O-benzyl-α-L-rhamnopyranoside With toluene-4-sulfonic acid In acetonitrile Stage #2: With acetic acid In water; acetonitrile	100%
Stage #1: Trimethyl orthoacetate; allyl 4-O-benzyl-α-L-rhamnopyranoside With toluene-4-sulfonic acid In acetonitrile at 20℃; for 1h; Stage #2: With acetic acid In water; acetonitrile at 20℃; for 1h; Cooling with ice;	98%
With toluene-4-sulfonic acid In acetonitrile 1a) 50 deg C, b) 12 h, r. t.;	85%

Trimethyl orthoacetate (1445-45-0) + 4-methoxy-5H-furan-2-one (69556-70-3) → methyl 5-(1,1-dimethoxyethyl)tetronate (82204-19-1)

Conditions	Yield
zinc dibromide	100%
With n-butyllithium; boron trifluoride diethyl etherate 1.) ether, hexane, -78 deg C, 2.) ether:THF=10:1, -78 deg C; Yield given. Multistep reaction;

Trimethyl orthoacetate (1445-45-0) + toluene-4-sulfonic acid (104-15-4) → methyl p-toluene sulfonate (80-48-8)

Conditions	Yield
at 20℃; for 0.5h;	100%
In dichloromethane for 0.5h; Ambient temperature;	96%

Trimethyl orthoacetate (1445-45-0) + methyl (4-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside (475672-28-7) → methyl (2-O-acetyl-4-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside (475672-29-8)

Conditions	Yield
Stage #1: Trimethyl orthoacetate; methyl (4-O-benzyl-α-L-rhamnopyranosyl)-(1->3)-2-acetamido-2-deoxy-4,6-O-isopropylidene-β-D-glucopyranoside With toluene-4-sulfonic acid In acetonitrile at 20℃; for 1h; Stage #2: With water; acetic acid at 20℃; for 0.5h; Further stages.;	100%

Trimethyl orthoacetate (1445-45-0) + allyl 2,6-di-O-benzyl-α-D-galactopyranoside (37111-91-4) → allyl 4-O-acetyl-2,6-di-O-benzyl-α-D-galactopyranoside (525585-38-0)

Conditions	Yield
Stage #1: Trimethyl orthoacetate; allyl 2,6-di-O-benzyl-α-D-galactopyranoside With pyridinium p-toluenesulfonate In acetonitrile for 0.166667h; Stage #2: With acetic acid In water; acetonitrile for 1.5h;	100%

Trimethyl orthoacetate (1445-45-0) + 4-aminosalicylic acid (2374-03-0) → 2-methyl-6-benzoxazole carboxylic acid (13452-14-7)

Conditions	Yield
at 100℃; for 0.0833333h; Microwave irradiation;	100%
at 100℃; for 0.0833333h; Microwave irradiation;	95%
	46%

Trimethyl orthoacetate (1445-45-0) + pentan-3-one (96-22-0) → 3,3-dimethoxypentane (25636-49-1)

Conditions	Yield
With p-toluenesulfonic acid monohydrate; sodium methylate In methanol	100%
With p-toluenesulfonic acid monohydrate In methanol at 5 - 20℃; for 3.5h;	100%

Trimethyl orthoacetate (1445-45-0) + 2-nitro-4-trifluoromethylbenzoic acid (320-94-5) → methyl 2-nitro-4-trifluoromethylbenzoate (228418-45-9)

Conditions	Yield
In toluene at 80℃; for 16h;	100%

Trimethyl orthoacetate (1445-45-0) + trifluoroacetic anhydride (407-25-0) → 1,1,1-trifluoro-4,4-dimethoxy-but-3-en-2-one (1071146-39-8)

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 18h;	100%
With pyridine In chloroform at 20℃; Cooling with ice;	92%
With pyridine In chloroform at 20℃; for 12h;	75%
With pyridine In chloroform at 20℃; for 12h; Inert atmosphere;	75%

Trimethyl orthoacetate (1445-45-0) + N-(2-bromo-4-(difluoromethoxy)phenyl)-6-chloro-2-methylpyrimidine-4,5-diamine (1198109-76-0) → 9-(2-bromo-4-(difluoromethoxy)phenyl)-6-chloro-2,8-dimethyl-9H-purine (1198109-77-1)

Conditions	Yield
With acetic acid In acetonitrile for 18h; Reflux;	100%

Trimethyl orthoacetate (1445-45-0) + C12H10F2N2O3S2*0.6ClH → methyl (1E)-N-({6-[(3,4-difluorophenyl)thio]-5-(hydroxymethyl)pyridin-3-yl}sulfonyl)ethanimidoate

Conditions	Yield
In acetonitrile at 85℃; for 18h;	100%

Trimethyl orthoacetate (1445-45-0) + 2-amino-6-bromo-N-methylbenzamide (1410973-85-1) → 5-bromo-2,3-dimethyl-3H-quinazolin-4-one (1410974-43-4)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane; 1-methyl-pyrrolidin-2-one at 110℃; for 9h;	100%

Trimethyl orthoacetate (1445-45-0) + ethylene glycol (107-21-1) → 2-(1-methoxy-ethoxy)-ethanol

Conditions	Yield
With trifluoroacetic acid In chloroform-d1 at 20℃; for 1h;	100%

Trimethyl orthoacetate (1445-45-0) + benzene-1,2-diol (120-80-9) → o-(1-methoxyethoxy)-phenol (51487-87-7)

Conditions	Yield
With trifluoroacetic acid In dimethylsulfoxide-d6 at 20℃; for 1h;	100%

Trimethyl orthoacetate (1445-45-0) + 2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) → C7H16O3

Conditions	Yield
With trifluoroacetic acid In dimethylsulfoxide-d6 at 20℃; for 1h;	100%

Trimethyl orthoacetate (1445-45-0) + 3-chloro-5-bromo-1,2-diaminobenzene (16429-44-0) → 5-bromo-7-chloro-2-methyl-1H-benzo[d]imidazole (16429-40-6)

Conditions	Yield
With ytterbium(III) triflate at 90℃; for 1h;	100%

Trimethyl orthoacetate (1445-45-0) + 3-methyl-2-buten-1-ol (556-82-1) → ethyl 3,3-dimethylpent-4-enoate (7796-72-7)

Conditions	Yield
With phenol at 130 - 160℃; for 16h; Johnson-Claisen Rearrangement; Inert atmosphere;	100%

Trimethyl orthoacetate (1445-45-0) + methylamine hydrochloride (593-51-1) → N-methyl-acetamide (79-16-3)

Conditions	Yield
In methanol at 135℃; for 0.25h; Microwave irradiation;	100%

Trimethyl orthoacetate (1445-45-0) + benzylamine hydrochloride (3287-99-8, 39110-74-2) → N-(phenylmethyl)acetamide (588-46-5)

Conditions	Yield
In methanol at 135℃; for 0.25h; Microwave irradiation;	100%

Trimethyl orthoacetate (1445-45-0) + 3-phenylpropylamine hydrochloride (30684-05-0) → N-acetyl-3-phenylpropylamine (34059-10-4)

Conditions	Yield
for 2h; Reflux;	100%

Trimethyl orthoacetate (1445-45-0) + amantadine hydrochloride (665-66-7) → N-(1-adamantyl)acetamide (880-52-4)

Conditions	Yield
In methanol at 135℃; for 0.25h; Microwave irradiation;	100%

Trimethyl orthoacetate (1445-45-0) + benzyl 4,6-O-benzylidene-α-D-mannopyranoside (73366-72-0) → benzyl 2-O-acetyl-4,6-O-benzylidene-α-D-glucopyranoside

Conditions	Yield
With (R)-10-camphorsulfonic acid In acetonitrile at 0 - 20℃; for 2h;	100%

Trimethyl orthoacetate (1445-45-0) + 7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one → 7-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2-methoxy-2-methyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-5-fluoro-3H-pyrrolo[2,3-d]pyrimidin-4-one

Conditions	Yield
In N,N-dimethyl-formamide at 60℃; for 1h;	100%

Trimethyl orthoacetate (1445-45-0) + 4-O-benzyl-3-O-(4-methoxybenzyloxy)-6-O-thexyldimethylsilyl-5a-carba-α-D-glucopyranose + acetic acid (64-19-7) → 1-O-acetyl-4-O-benzyl-3-O-(4-methoxybenzyloxy)-6-O-thexyldimethylsilyl-5a-carba-α-D-glucopyranose

Conditions	Yield
Stage #1: Trimethyl orthoacetate; 4-O-benzyl-3-O-(4-methoxybenzyloxy)-6-O-thexyldimethylsilyl-5a-carba-α-D-glucopyranose With toluene-4-sulfonic acid In acetonitrile at 20℃; for 1h; Inert atmosphere; Stage #2: acetic acid In water; acetonitrile for 1h; Inert atmosphere;	100%

Trimethyl orthoacetate (1445-45-0) + 1-octen-3-ol (3391-86-4) → methyl (4E)-dec-4-enoate (93979-14-7)

Conditions	Yield
With propionic acid at 125℃; for 2h; Temperature; Claisen Rearrangement;	99.5%
With propionic acid at 105℃; for 4.5h;	87%
With propionic acid at 100 - 105℃;

Trimethyl orthoacetate (1445-45-0) + 1,6-anhydro-2-azido-2-deoxy-β-D-galactopyranose (67313-36-4) → 1,6-Anhydro-2-azido-2-desoxy-3,4-O-(methyl-orthoacetyl)-β-D-galactopyranose (79705-76-3)

Conditions	Yield
With toluene-4-sulfonic acid In benzene for 0.666667h;	99%

Upstream product

• 67-56-1 methanol 
• 14777-27-6 methyl acetimidate hydrochloride 
• 922-69-0 1,1-dimethoxyethylene 
• 75-07-0 acetaldehyde 
• 60-29-7 diethyl ether 
• 82190-86-1 1-((2-chloroethyl)oxy)ethanimine hydrochloride 
• 79-20-9 acetic acid methyl ester 
• 594-72-9 1,1-dichloro-1-nitroethane 
• 124-41-4 sodium methylate 
• 149-73-5 trimethyl orthoformate 
• 78-39-7 Triethyl orthoacetate 
• 75-05-8 acetonitrile 

Downstream Products

• 5744-65-0 1,1,3,3-tetramethoxy-butane 
• 24851-20-5 6-methyl-5-p-tolyl-pyrimidine-2,4-diamine 
• 115716-99-9 2-(2,4-dichloro-phenyl)-3-methoxy-acrylonitrile 
• 18588-57-3 2,4-diamino-5-(3',4'-dichlorophenyl)-6-ethylpyrimidine 
• 40070-40-4 trimethyl 2-bromoorthoacetate 
• 73478-37-2 2-benzoyl-3-methoxy-crotononitrile 
• 13820-19-4 (1-phenylamino)ethylidene-propanedinitrile 
• 66977-22-8 2,2-Dimethoxycyclohexanonoxim-dimethylorthoacetat 
• 2568-83-4 5-Cyano-orthopentansaeure-trimethylester 
• 23081-59-6 <1,1-Dimethoxy-ethyl>-phenyl-phosphinsaeure-methylester 
• 110443-54-4 4-(1-methoxy-ethylidene)-3-phenyl-4H-isoxazol-5-one 
• 55865-49-1 3-Methyl-4,1'-methoxyethylidenisoxazolin-5-on 
• 662-16-8 1,1,1,3,3,3-hexafluoro-2-methoxy-propan-2-ol 
• 93-60-7 methyl 3-pyridinecarboxylate 

Relevant articles and documents

Process for producing high-quality trimethyl orthoacetate

The invention discloses a process for producing high-quality trimethyl orthoacetate. The process comprises the steps of: in the presence of a pseudocumene solvent, performing a salt-forming reaction on acetonitrile, methanol and hydrogen chloride to prepare ethylenediamine methyl ether hydrochloride, then putting the obtained ethylenediamine methyl ether hydrochloride in a methanol solution, adding an ammonium methanol solution dropwise so as to adjust the pH value, performing an alcoholysis reaction to obtain a crude product of trimethyl orthoacetate, performing filtration so as to remove solid ammonium chloride for recycling, performing adsorption on the obtained filtrate by using strongly alkaline macroporous ion exchange resin so as to remove chloride ions, and finally performing continuous rectification to obtain the trimethyl orthoacetate product which has a content of more than 99.5% and a yield of more than 85%. The process is simple, the product is stable and reliable, the adopted pseudocumene solvent has low toxicity and is safe to use.

Production process of high-quality trimethyl orthoacetate

The invention discloses a production process of high-quality trimethyl orthoacetate. The production process comprises the following steps: performing salification reaction on acetonitrile, methanol and chlorine hydride in the presence of a solvent unsym-trimethyl benzene, so as to obtain ethyleneimine methyl ether hydrochloride; then adding the ethyleneimine methyl ether hydrochloride into a methanol solution; dropwise adding an aminomethanol solution to regulate a pH value, performing alcoholysis reaction to obtain a trimethyl orthoacetate crude product; filtering out solid ammonium chloride, and recycling the solid ammonium chloride; adsorbing filtrate by use of strong-basicity macroporous ion-exchange resin so as to remove chloridion; and finally performing continuous rectification, thereby obtaining a trimethyl orthoacetate product with content greater than 999.5% and yield greater than 85%. The production process is simple in process, the product is stable and reliable, and the used unsym-trimethyl benzene solvent is low in toxicity and safe to use.

A hydrogen chloride producing toluene diisocyanate methyl-acetate production method

The invention discloses a method for producing trimethyl orthoacetate by utilizing hydrogen chloride (HCl) generated during production of toluene diisocynate (TDI). The method comprises the following steps: carrying out pressure boosting on a dried normal-pressure and low-temperature HCl waste gas taken as a byproduct during production of TDI and then feeding methyl alcohol into HCl so as to prepare an alcohol acid; carrying out a salt forming reaction on the alcohol acid and acetonitrile in an inert solvent so as to prepare an ethyleneimine methyl ether hydrochloride; feeding methyl alcohol twice, carrying out an alcoholysis reaction and distilling so as to prepare trimethyl orthoacetate. According to the method, dried normal-pressure and low-temperature HCl generated during the production of TDI is taken a raw material, namely, the recycling of a waste material is realized, so that the cost is lowered; the safety and the environmental friendliness are realized. The alcohol acid is prepared, so that the problems that the metering of HCl is inaccurate and the temperature is difficult to control because a large quantity of heat is released during the salt forming reaction are solved; the solvent with a high boiling point is used, so that the safe and environment-friendly problem that the solvent with a low boiling point is toxic and flammable is solved; the continuous rectification is carried out, so that the problem of long production cycle is solved. The yield of prepared trimethyl orthoacetate can reach 76% to 80%.

Trimethyl orthoacetate synthesis method

The present invention provides a trimethyl orthoacetate synthesis method, wherein acetonitrile and methanol are adopted as starting raw materials. The method comprises: 1) when acetonitrile, methanol and a non-polar solvent are subjected to mixing cooling in a reaction kettle to achieve a temperature of -20 to -5 DEG C, adding a small amount of a Gemini surfactant to the system, then introducing dried hydrogen chloride gas to make a molar ratio of acetonitrile to methanol to hydrogen chloride to the surfactant be 1:1-2:1.05-1.5:0.001-0.005 and make a mass ratio of acetonitrile to the non-polar solvent be 1:2-5, and carrying out a complete stirring reaction after introducing the hydrogen chloride gas so as to generate an ethylenediamine methyl ether hydrochloride; and 2) adding methanol having the amount 2-4 times the molar amount of the starting acetonitrile is added to the ethylenediamine methyl ether hydrochloride generated in the step 1), adjusting the pH value of the reaction system to 5-6.5, carrying out an alcoholysis reaction at a temperature of 25-40 DEG C, filtering the alcoholysis product, and refining to obtain the trimethyl orthoacetate. With the method of the present invention, the water content of the original ester synthesis system can be completely reduced so as to significantly improve the trimethyl orthoacetate yield.

Orthoester exchange: A tripodal tool for dynamic covalent and systems chemistry

Reversible covalent reactions have become an important tool in supramolecular chemistry and materials science. Here we introduce the acid-catalyzed exchange of O,O,O-orthoesters to the toolbox of dynamic covalent chemistry. We demonstrate that orthoesters readily exchange with a wide range of alcohols under mild conditions and we disclose the first report of an orthoester metathesis reaction. We also show that dynamic orthoester systems give rise to pronounced metal template effects, which can best be understood by agonistic relationships in a three-dimensional network analysis. Due to the tripodal architecture of orthoesters, the exchange process described herein could find unique applications in dynamic polymers, porous materials and host-guest architectures.

Divergent Diels-Alder methodology from methyl coumalate toward functionalized aromatics

An inverse electron-demand Diels-Alder reaction between methyl coumalate and electron-rich dienophiles produces substituted benzoates. A high-yielding, single-pot procedure transforms readily accessible vinyl ether, ketal, or orthoester dienophiles into functionalized aromatic systems in a versatile route.

METHOD FOR PRODUCING IMIDE ETHER COMPOUND

A method for producing an imide ether compound in high yield is provided. The method is characterized in that a nitrile compound, an alcohol and a hydrogen halide are continuously introduced into a flow reaction apparatus comprising a mixing vessel and a flow reactor, to react them with one another. Since the reaction proceeds with 1 : 1 by the use of a flow reactor, an improved selectivity is achieved and the formation of a by-product is reduced, which results in the efficient production of an imide ether compound.

New phenylalanine derivatives

Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

Influence of Solvent and Counterion in the Reactions of Alkoxide Ions with the 2-Nitropropan-2-yl Radical

Photostimulated free radical chain reactions between alkoxide ions derived from primary alcohols and XCMe2NO2 (X= Cl, Br, NO2, PhSO2, N3, or p-ClC6H4S) occur to produce Me2C(OR)2 by reaction involving the trapping of Me2C(NO2). by RO-, the decomposition of ROCMe2NO2.- to ROCMe2., and the oxidation of ROCMe2. to Me2C=OR+ by XCMe2NO2.