498-60-2Relevant articles and documents
Rhodium-catalyzed reductive carbonylation of aryl iodides to arylaldehydes with syngas
Chen, Suqing,Liu, Zhenghui,Mu, Tiancheng,Wang, Peng,Yan, Zhenzhong,Yu, Dongkun,Zhao, Xinhui
, p. 645 - 656 (2020/05/14)
The reductive carbonylation of aryl iodides to aryl aldehydes possesses broad application prospects. We present an efficient and facile Rh-based catalytic system composed of the commercially available Rh salt RhCl3·3H2O, PPh3 as phosphine ligand, and Et3N as the base, for the synthesis of arylaldehydes via the reductive carbonylation of aryl iodides with CO and H2 under relatively mild conditions with a broad substrate range affording the products in good to excellent yields. Systematic investigations were carried out to study the experimental parameters. We explored the optimal ratio of Rh salt and PPh3 ligand, substrate scope, carbonyl source and hydrogen source, and the reaction mechanism. Particularly, a scaled-up experiment indicated that the catalytic method could find valuable applications in industrial productions. The low gas pressure, cheap ligand and low metal dosage could significantly improve the practicability in both chemical researches and industrial applications.
Peptidylarginine deiminase inhibitor and application thereof
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Paragraph 0834; 0839; 0840; 0841, (2019/09/10)
The invention belongs to the technical field of medicine, and particularly relates to a peptidylarginine deiminase PAD4 inhibitor compound shown in a formula (I) or pharmaceutically acceptable salts,stereoisomers and tautomers thereof, as well as pharmaceutical compositions, pharmaceutical preparations and application thereof. X, Y, R1, R2, R3, R4, R5, R7, R8, R9, ring B and m are as defined in the specification. The compound has inhibitory effect on peptidylarginine deiminase PAD4, and can be used for treating various diseases, such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, multiple sclerosis, cystic fibrosis, cancer, cutaneous lupus erythematosus, asthma and psoriasis.
Rhodium-Catalyzed Formylation of Aryl Halides with CO2 and H2
Liu, Zhenghui,Yang, Zhenzhen,Yu, Bo,Yu, Xiaoxiao,Zhang, Hongye,Zhao, Yanfei,Yang, Peng,Liu, Zhimin
, p. 5130 - 5134 (2018/09/13)
The reductive formylation of aryl iodides/bromides to aryl aldehydes using CO2/H2 is presented for the first time. It was realized over a catalytic system composed of RhI3 or RhI3/Pd(dppp)Cl2 (dppp = 1,3-bis(diphenyphosphino)propane) and PPh3 in the presence of Ac2O/Et3N at 100 °C, affording aromatic aldehydes in good to excellent yields, together with good functional-group tolerance and broad substrate scope. The reaction proceeds through three cascade steps, involving HCOOH formation, CO release, and formylation of aryl halides.
A 3 - furfural types of the product of preparation method (by machine translation)
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Paragraph 0020; 0021, (2018/03/25)
The invention discloses a 3 - furfural such product of preparation method, selecting palladium catalyst, heteropoly acid catalyst and Lewis acid catalyst is dissolved in a concentration of 1 mol/L solvent three-opening in the bottle, the water bath is heated to 40 - 90 °C; selecting the α, β - unsaturated carboxylic acid ester and fatty aldehyde phase mixing, the mixed solution is added to the flask in, then in 40 - 90 °C stirring under reflux reaction; to after the completion of the reaction, adding the extractant after separating distilled under reduced pressure to obtain 3 - furfuryl acid esters, a reducing agent is added to the reaction flask in 3 - furfural types of product. This invention adopts the α, β - unsaturated carboxylic acid esters, aliphatic aldehydes and heteropoly acid catalyst and the like, are commonly used chemical reagent, low cost, easy operation, can carry out a large number of production, small pollution to the environment, it is environment-friendly reaction; at the same time the invention the provided 3 - furfural types of product, it is a kind of has a wide application prospect of intermediate, its downstream product synthesis and application of, with broad application prospect. (by machine translation)
Aerobic Oxidation of Alcohols to Carbonyl Compounds Catalyzed by N-Hydroxyphthalimide (NHPI) Combined with CoTPP-Zn2Al-LDH
Zhou, Weiyou,Chen, Dongwei,Cui, Aijun,Qian, Junfeng,He, Mingyang,Chen, Qun
, p. 295 - 299 (2017/03/23)
A catalytic system for the aerobic oxidation of alcohols by N-hydroxyphthalimide (NHPI) combined with cobalt porphyrin intercalated heterogeneous hybrid catalyst (CoTPP-Zn 2Al-LDH) has been developed. The results showed that this catalytic system can effectively catalyze the oxidation of alcohols to the corresponding carbonyl compounds. And the hybrid catalyst can be reused for five times with no appreciable reduction of activity. [Figure not available: see fulltext.]
Heterogeneous Sodium-Manganese Oxide Catalyzed Aerobic Oxidative Cleavage of 1,2-Diols
Escande, Vincent,Lam, Chun Ho,Coish, Philip,Anastas, Paul T.
supporting information, p. 9561 - 9565 (2017/08/01)
The aerobic oxidative cleavage of 1,2-diols using a heterogeneous catalyst only based on earth-abundant metals manganese and sodium is reported for the first time. This reusable catalyst cleaves a variety of substrates into aldehydes or ketones with high selectivity. The reaction requires small catalytic loadings and is performed under mild conditions using ambient pressure O2 or air as the oxidant while producing water as the only by-product. Mechanistic investigations reveal a monodentate, two-electron oxidative fragmentation process involving a MnIV species. The eco-friendly, innocuous catalyst is compatible with a wide range of functional groups and conditions, making it highly competitive with classical reagents, such as periodic acid or lead tetraacetate, as a preferred method for activated 1,2-diols.
A general and efficient zinc-catalyzed oxidation of benzyl alcohols to aldehydes and esters
Wu, Xiao-Feng
experimental part, p. 8912 - 8915 (2012/09/22)
Go green: A general and efficient zinc-catalyzed oxidation of benzyl alcohols has been developed. In the presence of a zinc catalyst, various aldehydes and esters have been prepared in good to excellent yields under mild conditions (see scheme).
Palladium-catalyzed direct oxidation of alkenes with molecular oxygen: General and practical methods for the preparation of 1, 2-diols, aldehydes, and ketones
Wang, Azhong,Jiang, Huanfeng
supporting information; experimental part, p. 2321 - 2326 (2010/07/04)
(Figure Presented) 1, 2-Diols, aldehydes, and ketones are important intermediates in chemical synthesis, and alkenes are possible precursors for 1, 2-diols, aldehydes, and ketones. Herein, novel and environmentally benign methods for palladium-catalyzed dihydroxylation and oxidative cleavage of olefins with oxygen as sole oxidant are presented. The cleavage reactions were performed with acid as additive in aqueous solution, whereas 1, 2-diols were formed in the presence of base. A broad substrate scope has been demonstrated allowing monosubstituted aromatic and aliphatic terminal alkenes, 1, 2-disubstituted, and 1, 1-disubstituted olefins. The cleavage reactions of dioxo-PdII complexes implicate 1, 2-diol might act as a key intermediate of olefin cleavage.
GAS PHASE REACTION PROCESS FOR POLYHYDRIC COMPOUNDS
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Page/Page column 20-21, (2008/12/07)
The present invention provides processes for the gas phase conversion of a polyhydric feedstock into an oxygen-containing product. The polyhydric feedstock comprises water and at least one polyhydric compound having from about four to about twelve carbon atoms and more than three hydroxyl groups. Also provided are processes for the separation of the oxygen-containing product from the reaction product mixture.
