609-09-6Relevant articles and documents
Convergent Synthesis of Dihydropyrans from Catalytic Three-Component Reactions of Vinylcyclopropanes, Diazoesters, and Diphenyl Sulfoxide
Zhang, Ya-Lin,Guo, Rui-Ting,Luo, Heng,Liang, Xin-Shen,Wang, Xiao-Chen
supporting information, p. 5627 - 5632 (2020/07/14)
A novel Rh(I)/La(III) cocatalytic three-component reaction of vinylcyclopropanes, diazoesters, and diphenyl sulfoxide has been developed. The reaction gives polysubstituted dihydropyrans as the reaction products. Mechanistic studies indicate that isomerization of vinylcyclopropanes gives conjugated dienes, which then undergo [4 + 2]-cycloaddition with vicinal tricarbonyl compounds generated by oxygen atom transfer from diphenyl sulfoxide to diazoesters.
Synthetic method of diacetate mono-hydrate of ketomalonic acid (by machine translation)
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Paragraph 0016-0017, (2019/11/28)
The reaction solution is slowly cooled to room temperature and stirred overnight under a weak acid and water environment, and the obtained reaction solution B is stirred at room temperature and stirred overnight, and after the A reaction is finished, the required compound of diethyl malonate monohydrate is obtained through extraction, 50 - 80 °C washing, drying, filtration and concentration 3 - 5 B. The synthesis method of the diacetate mono-hydrate of the ketomalonic acid has the advantages of simple reaction, easily available A raw materials, simple post-treatment, low cost, strong B operability and high industrial value. (by machine translation)
PRODUCTION METHOD OF KETOMALONIC ACID COMPOUND
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Paragraph 0212; 0213; 0214; 0215; 0216; 0217; 0218-0220, (2016/08/10)
Provided is a method for producing an industrially useful ketomalonic acid compound such as ketomalinic acid diesters, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1) (in the formula, The each Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general formula (2) (in the formula, R has the same meaning as above), or a hydrate thereof.
Production method of ketomalonic acid compound
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Paragraph 0232; 0233; 0237; 0238; 0239; 0240; 0241-0245, (2016/12/07)
Provided is a method for producing an industrially useful ketomalonic acid diesters or other ketomalonic acid compound, or a hydrate thereof, by a method more favorable from an economic and environmental standpoint and from a safety standpoint. The present invention relates to a method involving reacting a malonic acid compound represented by general formula (1) (in the formula, the Rs indicate an alkyl group, a cycloalkyl group, etc.) with chlorine dioxide to produce a ketomalonic acid compound represented by the general expression (2) (in the formula, R has the same meaning as above), or a hydrate thereof.
Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate
Sivan, Akhil,Deepthi, Ani
supporting information, p. 1890 - 1893 (2014/03/21)
A mild and efficient protocol for the synthesis of vicinal tricarbonyl compounds from β-dicarbonyls in a single step using cerium(IV) ammonium nitrate as a catalytic oxidant is described. Ease of execution, wide substrate scope and the suitability for the synthesis of commercially important compounds like ninhydrin, alloxan and oxoline make this reaction particularly noteworthy.
PROCESS FOR PRODUCTION OF KETOMALONIC ACID COMPOUNDS OR HYDRATES THEREOF
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Page/Page column 8, (2012/01/14)
Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization.
Preparation process for alpha , beta -dicarbonylated compounds
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, (2008/06/13)
Preparation process for alpha , beta -dicarbonylated compounds of formula (I) in which R2=alkyl, phenyl or benzyl being able to be substituted in various ways on the cycle, or carboxylic ester, and R3=alkyl or alkoxy or carboxylic ester in which a compound of formula (II) in which R1=alkyl, or alkyl alpha -ketocarboxylate or carboxylic ester, and R2 and R3 have the same meanings as previously is reacted in a nitrile type solvent, with molecular oxygen in the presence of copperII nitrate or ferric chloride as catalyst, and use for obtaining ethyl alpha -ketobutyrate, ethyl phenyl pyruvate, ethyl pyruvate, ethyl phenylglyoxylate, butane-2,3-dione or diethyl mesoxalate.
CHEMISTRY OF NITRO ESTERS XVII. METHOD FOR THE PRODUCTION OF MESOXALIC ESTERS
Kochergin, P. M.,Titkova, R. M.
, p. 1042 - 1044 (2007/10/02)
A new preparative method was developed for the production of mesoxalic esters from bromomalonic esters and silver nitrate
Process for the preparation of monocarbonyl or biscarbonyl compounds
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, (2008/06/13)
The invention relates to a process for the preparation of monocarbonyl or biscarbonyl compounds by reacting organic carbon compounds having one or more olefinic or aromatic double bonds in the molecule with the equivalent amount of ozone and by subsequently catalytically hydrogenating the ozonization products, wherein the peroxide-containing ozonization solution is fed continuously into a suspension of the hydrogenation catalyst in a lower aliphatic alcohol, while a peroxide content of not more than 0.1 mole/l is maintained, and the ozonization products are continuously cleaved reductively to give the corresponding carbonyl compounds.
