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70-23-5 Usage

Chemical Properties

Clear yellow to pink-red liquid

Uses

Different sources of media describe the Uses of 70-23-5 differently. You can refer to the following data:
1. Employed in a synthesis of thioxothiazolidines from primary amines and carbon disulfide.1
2. Ethyl 3-bromopyruvate is employed in a synthesis of thioxothiazolidines from primary amines and carbon disulfide.

Hazard

Severe poison, lachrymator, irritant.

Purification Methods

The most likely impurity is free acid (bromopyruvic or bromoacetic acids). Dissolve the ester in dry Et2O or dry CHCl3, stir with CaCO3 until effervescence ceases, filter, (may wash with a little H2O rapidly), dry (MgSO4) and distil it at least twice. The 2,4-dinitrophenylhydrazone has m 144-145o. [Burros & Holland J Chem Soc 672 1947, Letsinger & Laco J Org Chem 21 764 1956, Kruse et al. J Am Chem Soc 76 5796 1954, Beilstein 3 IV 1519.] LACHRYMATORY.

Check Digit Verification of cas no

The CAS Registry Mumber 70-23-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 0 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 70-23:
(4*7)+(3*0)+(2*2)+(1*3)=35
35 % 10 = 5
So 70-23-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H7BrO3/c1-2-9-5(8)4(7)3-6/h2-3H2,1H3

70-23-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (L00582)  Ethyl 3-bromopyruvate, tech. 75%   

  • 70-23-5

  • 5g

  • 148.0CNY

  • Detail
  • Alfa Aesar

  • (L00582)  Ethyl 3-bromopyruvate, tech. 75%   

  • 70-23-5

  • 25g

  • 485.0CNY

  • Detail
  • Alfa Aesar

  • (L00582)  Ethyl 3-bromopyruvate, tech. 75%   

  • 70-23-5

  • 100g

  • 1325.0CNY

  • Detail

70-23-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl bromopyruvate

1.2 Other means of identification

Product number -
Other names ethyl 3-bromo-2-oxopropanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:70-23-5 SDS

70-23-5Synthetic route

2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

Conditions
ConditionsYield
With tetrachloromethane; bromine at 50 - 60℃; unter Durchleiten von trockener Luft und Belichtung;
With bromine at 50 - 60℃;
With bromine at 65℃; unter Durchleiten von CO2;
tetrachloromethane
56-23-5

tetrachloromethane

N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

A

2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

B

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

methyl lactate
547-64-8

methyl lactate

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

Conditions
ConditionsYield
With tetrachloromethane; N-Bromosuccinimide
ethyl diazopyruvate
14214-10-9

ethyl diazopyruvate

A

bromopyruvic acid
1113-59-3

bromopyruvic acid

B

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

Conditions
ConditionsYield
With diethyl ether; hydrogen bromide
tetrachloromethane
56-23-5

tetrachloromethane

N-Bromosuccinimide
128-08-5

N-Bromosuccinimide

ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

calcium carbonate

calcium carbonate

A

2-oxo-propionic acid ethyl ester
617-35-6

2-oxo-propionic acid ethyl ester

B

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl 2-hydroxypropionate
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-bromo-succinimide; calcium carbonate; tetrachloromethane
2: N-bromo-succinimide; tetrachloromethane; hydrogen bromide
View Scheme
ethanol
64-17-5

ethanol

bromopyruvic acid
1113-59-3

bromopyruvic acid

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

Conditions
ConditionsYield
hydrogenchloride In water at 30 - 40℃; for 9h;
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

thiourea
17356-08-0

thiourea

2-aminothiazole-4-carboxylate
5398-36-7

2-aminothiazole-4-carboxylate

Conditions
ConditionsYield
In ethanol at 70℃; for 1h;100%
In ethanol at 70℃; for 1h; Hantzsch Thiazole Synthesis;100%
at 120℃; for 0.5h;99.5%
Ethyl diphenylphosphinite
719-80-2

Ethyl diphenylphosphinite

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

diphenylphosphinicoenolpyruvate d'ethyle
130742-47-1

diphenylphosphinicoenolpyruvate d'ethyle

Conditions
ConditionsYield
Ambient temperature;100%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2,2-diethoxythioacetamide
73956-15-7

2,2-diethoxythioacetamide

ethyl 2-(diethoxymethyl)-1,3-thiazole-4-carboxylate
73956-16-8

ethyl 2-(diethoxymethyl)-1,3-thiazole-4-carboxylate

Conditions
ConditionsYield
With 3 A molecular sieve In ethanol for 0.5h; Heating;100%
With 4 A molecular sieve In ethanol for 1h; Hantzsch reaction; Heating;100%
With 4 Angstroem MS In ethanol for 1h; Heating;100%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

diethyl phenylphosphonite
1638-86-4

diethyl phenylphosphonite

2-(Ethoxy-phenyl-phosphinoyloxy)-acrylic acid ethyl ester
130742-45-9

2-(Ethoxy-phenyl-phosphinoyloxy)-acrylic acid ethyl ester

Conditions
ConditionsYield
Ambient temperature;100%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

hydroxylamine hydrochloride
5470-11-1

hydroxylamine hydrochloride

ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate
127033-04-9

ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate

Conditions
ConditionsYield
In methanol; chloroform for 16h; Ambient temperature;100%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

L-cysteine ethyl ester hydrochloride
868-59-7

L-cysteine ethyl ester hydrochloride

diethyl (R)-3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylate
94110-58-4

diethyl (R)-3,4-dihydro-2H-1,4-thiazine-3,5-dicarboxylate

Conditions
ConditionsYield
With triethylamine In dichloromethane100%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

O-benzylhydoxylamine hydrochloride
2687-43-6

O-benzylhydoxylamine hydrochloride

ethyl α-(benzyloximino)-β-bromopropanoate
81095-88-7

ethyl α-(benzyloximino)-β-bromopropanoate

Conditions
ConditionsYield
In methanol; chloroform for 16h; Ambient temperature;100%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

(S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester
96929-02-1

(S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester

2-<(S)-1--2-methylpropyl>-4-carbethoxythiazole
96929-07-6

2-<(S)-1--2-methylpropyl>-4-carbethoxythiazole

Conditions
ConditionsYield
Stage #1: (S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester With potassium hydrogencarbonate In 1,2-dimethoxyethane at -15℃; for 0.333333h; Inert atmosphere;
Stage #2: ethyl Bromopyruvate In 1,2-dimethoxyethane at -15 - 20℃; for 0.75h; Inert atmosphere;
Stage #3: With 2,6-dimethylpyridine; trifluoroacetic anhydride In 1,2-dimethoxyethane at -15 - 20℃; for 13.5h; Inert atmosphere;
100%
Stage #1: ethyl Bromopyruvate; (S)-(2-methyl-1-thiocarbamoylpropyl)carbamic acid tert-butyl ester With potassium hydrogencarbonate In 1,2-dimethoxyethane at -15℃; Hantzsch reaction;
Stage #2: With 2,3,5-trimethyl-pyridine; trifluoroacetic anhydride at -15℃; Hantzsch reaction;
78%
In diethyl ether for 48h; Ambient temperature;42%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl 3-bromo-2-(hydroxyimino)propanoate
73472-94-3

ethyl 3-bromo-2-(hydroxyimino)propanoate

Conditions
ConditionsYield
With hydroxylamine hydrochloride In chloroform; water at 23℃;100%
With hydroxyammonium sulfate In chloroform; water at 20℃; for 3h;95%
With hydroxylamine88%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

1,3-cylohexanedione
504-02-9

1,3-cylohexanedione

3-hydroxy-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-3-carboxylic acid ethyl ester
128428-59-1

3-hydroxy-4-oxo-2,3,4,5,6,7-hexahydrobenzofuran-3-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium hydroxide In methanol Ambient temperature; overnight;100%
With 1-butyl-3-methylimidazolium hydroxide at 25 - 30℃; for 0.5h; Feist-Benary reaction;88%
Stage #1: 1,3-cylohexanedione With ammonium acetate In ethanol; water at 80℃; for 1h;
Stage #2: ethyl Bromopyruvate In ethanol; water at 80℃; for 3h;
88%
With sodium hydroxide In methanol for 12h; microwave heating;
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2,4-difluorobenzene-1-carbothioamide
175276-92-3

2,4-difluorobenzene-1-carbothioamide

ethyl 2-(2,4-difluorophenyl)thiazole-4-carboxylate
175276-93-4

ethyl 2-(2,4-difluorophenyl)thiazole-4-carboxylate

Conditions
ConditionsYield
In ethanol for 3h; Heating / reflux;100%
C9H14N2O2S2
952723-33-0

C9H14N2O2S2

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

C14H18N2O4S2

C14H18N2O4S2

Conditions
ConditionsYield
In ethanol for 1h; Hantzsch thiazole synthesis; Heating;100%
C9H14N2O2S2
952723-33-0

C9H14N2O2S2

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl 2'-formyl-2,4'-bithiazole-4-carboxylate
190523-39-8

ethyl 2'-formyl-2,4'-bithiazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: C9H14N2O2S2; ethyl Bromopyruvate In ethanol for 1h; Hantzsch thiazole synthesis; Heating;
Stage #2: With hydrogenchloride In acetone for 1.5h; Heating; Further stages.;
100%
ethyl-2-thiourea
625-53-6

ethyl-2-thiourea

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2-ethylamino-thiazole-4-carboxylic acid ethyl ester*HBr
262372-88-3

2-ethylamino-thiazole-4-carboxylic acid ethyl ester*HBr

Conditions
ConditionsYield
In 1,4-dioxane Heating / reflux;100%
2-amino-2-thioxoethyl 5-({[(benzyloxy)carbonyl]amino}methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinate
851581-25-4

2-amino-2-thioxoethyl 5-({[(benzyloxy)carbonyl]amino}methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinate

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]methyl 5-({[(benzyloxy)carbonyl]amino}methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinate
851581-26-5

[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]methyl 5-({[(benzyloxy)carbonyl]amino}methyl)-6-isobutyl-2-methyl-4-(4-methylphenyl)nicotinate

Conditions
ConditionsYield
In ethanol for 1h; Heating / reflux;100%
2-aminopyrimidine
109-12-6

2-aminopyrimidine

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2-amino-1H-imidazole-4-carboxylic acid ethyl ester
149520-94-5

2-amino-1H-imidazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: 2-aminopyrimidine; ethyl Bromopyruvate In ethanol at 75℃; for 16h; Inert atmosphere;
Stage #2: With hydrazine hydrate In ethanol at 75℃; for 16h; Inert atmosphere;
100%
Stage #1: 2-aminopyrimidine; ethyl Bromopyruvate In ethanol at 75℃;
Stage #2: With hydrazine hydrate In ethanol at 75℃;
54%
Stage #1: 2-aminopyrimidine; ethyl Bromopyruvate In ethanol at 75℃; for 18h;
Stage #2: With hydrazine hydrate In ethanol at 75℃; for 16.5h;
0.34 g
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

p-bromobenzamide
698-67-9

p-bromobenzamide

ethyl 2-(4-bromphenyl)-1,3-oxazole-4-carboxylate
391248-23-0

ethyl 2-(4-bromphenyl)-1,3-oxazole-4-carboxylate

Conditions
ConditionsYield
With silver hexafluoroantimonate In 1,2-dichloro-ethane at 90℃; for 2h; Inert atmosphere; Microwave irradiation;100%
With silver hexafluoroantimonate In dichloromethane at 90℃; under 3750.38 Torr; for 1h; Sealed tube; Microwave irradiation;
In ethanol at 70℃; for 5h;
Stage #1: ethyl Bromopyruvate; p-bromobenzamide With sodium hydrogencarbonate In tetrahydrofuran at 60℃; for 23h;
Stage #2: With trifluoroacetic anhydride In tetrahydrofuran at 20℃; for 12h;
4-amino-2,6-dichloropyrimidine
10132-07-7

4-amino-2,6-dichloropyrimidine

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl 7-chloro-5-hydroxyimidazo[1,2-c]pyrimidine-2-carboxylate

ethyl 7-chloro-5-hydroxyimidazo[1,2-c]pyrimidine-2-carboxylate

Conditions
ConditionsYield
With acetic acid at 120℃; for 2h; Inert atmosphere;100%
In acetic acid at 120℃; for 2h;98%
ISOPROPYLAMIDE
563-83-7

ISOPROPYLAMIDE

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2-isopropyl-thiazole-4-carboxylic acid ethyl ester
133047-44-6

2-isopropyl-thiazole-4-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ISOPROPYLAMIDE With Lawessons reagent In tetrahydrofuran at 70℃; for 24h;
Stage #2: ethyl Bromopyruvate In tetrahydrofuran at 70℃; for 48h;
100%
5-bromo-3-(trifluoromethyl)pyridin-2-amine
79456-34-1

5-bromo-3-(trifluoromethyl)pyridin-2-amine

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

6-bromo-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester
1121051-30-6

6-bromo-8-trifluoromethyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

Conditions
ConditionsYield
In N,N-dimethyl-formamide at 50℃; for 16h;99.5%
In N,N-dimethyl-formamide at 50℃; for 24h;89%
In N,N-dimethyl-formamide at 50℃; for 24h;89%
2,3,5-tri-O-benzoyl-β-L-(+)-ribofuranosyl-1-thiocarboxamide

2,3,5-tri-O-benzoyl-β-L-(+)-ribofuranosyl-1-thiocarboxamide

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

Ethyl 2-(2', 3', 5'-Tri-O-benzoyl-β-L(+)-ribofuranosyl)thiazole-4-carboxylate
206269-63-8

Ethyl 2-(2', 3', 5'-Tri-O-benzoyl-β-L(+)-ribofuranosyl)thiazole-4-carboxylate

Conditions
ConditionsYield
Stage #1: 2,3,5-tri-O-benzoyl-β-L-(+)-ribofuranosyl-1-thiocarboxamide; ethyl Bromopyruvate With sodium hydrogencarbonate In 1,2-dimethoxyethane at 0℃; for 6h;
Stage #2: With 2,6-dimethylpyridine; trifluoroacetic anhydride In 1,2-dimethoxyethane at -15℃; for 2h;
99%
2-amino-4-bromo-6-ethoxycarbonylpyridine
865604-39-3

2-amino-4-bromo-6-ethoxycarbonylpyridine

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

C13H13BrN2O4
1021150-13-9

C13H13BrN2O4

Conditions
ConditionsYield
In ethanol at 60℃;99%
Stage #1: 2-amino-4-bromo-6-ethoxycarbonylpyridine; ethyl Bromopyruvate In ethanol at 23 - 80℃; for 3h;
Stage #2: With sodium hydrogencarbonate In water at 23℃; for 20h;
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

(4-fluoro-phenyl)-thiourea
459-05-2

(4-fluoro-phenyl)-thiourea

ethyl 2-((4-fluorophenyl)amino)thiazole-4-carboxylate

ethyl 2-((4-fluorophenyl)amino)thiazole-4-carboxylate

Conditions
ConditionsYield
In ethanol Reflux;99%
With sodium carbonate In neat (no solvent) Milling;80%
In ethanol at 65℃;
In ethanol at 65℃; for 2h;
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate
127033-04-9

ethyl (2Z)-3-bromo-2-(hydroxyimino)propanoate

Conditions
ConditionsYield
With hydroxylamine sulfate In chloroform; water at 20℃; for 24h;99%
With hydroxylamine hydrochloride In methanol; chloroform; water at 25℃; for 22h; Inert atmosphere;86%
With hydroxyammonium sulfate In chloroform; water at 20℃; for 24h;
With hydroxylamine hydrochloride In water; toluene at 15 - 25℃; Large scale;
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

5-(2,6-dimethylpyridin-4-yl)-2-(methylthio)-6-phenylpyrimidin-4-amine

5-(2,6-dimethylpyridin-4-yl)-2-(methylthio)-6-phenylpyrimidin-4-amine

ethyl 8-(2,6-dimethylpyridin-4-yl)-5-(methylthio)-7-phenylimidazo[1,2-c]pyrimidine-2-carboxylate

ethyl 8-(2,6-dimethylpyridin-4-yl)-5-(methylthio)-7-phenylimidazo[1,2-c]pyrimidine-2-carboxylate

Conditions
ConditionsYield
In 1,2-dimethoxyethane at 110℃; for 2h;99%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

triphenylphosphine
603-35-0

triphenylphosphine

(2-Ethoxycarbonyl-2-oxo-ethyl)-triphenyl-phosphonium; bromide

(2-Ethoxycarbonyl-2-oxo-ethyl)-triphenyl-phosphonium; bromide

Conditions
ConditionsYield
In toluene at 100℃; for 6h; Inert atmosphere;98.5%
In tetrachloromethane for 36h; Ambient temperature;
In toluene for 3h; Yield given;
In tetrachloromethane at 20℃; for 36h;
With magnetic iron oxide nanoparticles (Fe3O4-MNPs) In neat (no solvent) at 80℃; for 0.75h; Green chemistry;
5-bromo-2-pyridylamine
1072-97-5

5-bromo-2-pyridylamine

ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

ethyl 6-bromoimidazo<1,2-a>pyridine-2-carboxylate
67625-37-0

ethyl 6-bromoimidazo<1,2-a>pyridine-2-carboxylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 12h;98%
With magnesium sulfate In 1,4-dioxane at 80℃; for 18h;93%
Stage #1: 5-bromo-2-pyridylamine; ethyl Bromopyruvate In 1,2-dimethoxyethane for 5h;
Stage #2: In ethanol Reflux;
87%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

thiourea
17356-08-0

thiourea

2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide

2-amino-4-ethoxycarbonyl-1,3-thiazolehydrobromide

Conditions
ConditionsYield
In ethyl acetate at 60 - 110℃; Cooling;98%
In ethanol at 78℃; for 1h;90%
at 100℃; for 1h;87%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

triphenylphosphine
603-35-0

triphenylphosphine

1,4-diphenyl-but-2-yne-1,4-dione
1087-09-8

1,4-diphenyl-but-2-yne-1,4-dione

ethyl 1-benzoyl-6-(bromomethyl)-2,2,2,4-tetraphenyl-3,7-dioxa-2λ5-phosphabicyclo[3.2.0]hept-4-ene-6-carboxylate

ethyl 1-benzoyl-6-(bromomethyl)-2,2,2,4-tetraphenyl-3,7-dioxa-2λ5-phosphabicyclo[3.2.0]hept-4-ene-6-carboxylate

Conditions
ConditionsYield
In diethyl ether at 20℃; for 40h;98%
ethyl Bromopyruvate
70-23-5

ethyl Bromopyruvate

2,2,2-trideuterio-thioacetamide
13386-16-8

2,2,2-trideuterio-thioacetamide

C7H6(2)H3NO2S
1443118-25-9

C7H6(2)H3NO2S

Conditions
ConditionsYield
In d(4)-methanol98%

70-23-5Relevant articles and documents

Method for synthesizing pharmaceutical intermediate 2-aminothiazole-4-ethyl formate

-

Paragraph 0010, (2018/07/30)

The invention discloses a method for synthesizing a pharmaceutical intermediate 2-aminothiazole-4-ethyl formate, ethyl pyruvate, dichloromethane, concentrated sulfuric acid, bromine, ethyl bromopyruvate, thiourea and ethanol are used as main raw materials, and a main factor affecting the product yield during cyclization reaction is the ratio of the important intermediate ethyl bromopyruvate to thethiourea. According to experimental procedures, the ethanol is selected as a solvent, nanocatalyst Cu2O@HKUST-1 is added, under reflux conditions, a desired product with a higher yield can be obtained by optimizing of the material ratio, the intermediate catalyst used in the method shortens the reaction cycle, a solid carbonate is used to adjust the pH of the reaction liquid, the generation of wastewater is reduced, and economic benefits are increased.

A pharmaceutical intermediates for synthesis and its preparation method (by machine translation)

-

Paragraph 0041; 0042, (2017/11/04)

The present invention discloses a pharmaceutical intermediates for synthesis and its preparation method, its structural formula is as follows: Wherein R1 C is hydrogen or1 - C4 The alkane, R2 For C1 - C4 The alkane. The intermediate for the synthesis of 2 - isopropyl-thiazole - 4 - carboxylic acid ethyl ester, every one-step reaction conditions are easy to control, product yield and purity are very high, the operating procedure is simplified, basic does not need to be purified, and further reducing the cost of the final product. (by machine translation)

An efficient total synthesis of (-)-epothilone B

Wang, Jie,Sun, Bing-Feng,Cui, Kai,Lin, Guo-Qiang

supporting information, p. 6354 - 6357 (2013/02/23)

An efficient total synthesis of (-)-epothilone B has been achieved in ca. 8% yield over 11 steps from 9 (or 10 steps from 7/8), which features a bissiloxane-tethered ring closing metathesis reaction to approach the trisubstituted (Z) double bond and forms a new basis for further development of an industrial process for epothilone B and ixabepilone.

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