70-23-5Relevant articles and documents
Method for synthesizing pharmaceutical intermediate 2-aminothiazole-4-ethyl formate
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Paragraph 0010, (2018/07/30)
The invention discloses a method for synthesizing a pharmaceutical intermediate 2-aminothiazole-4-ethyl formate, ethyl pyruvate, dichloromethane, concentrated sulfuric acid, bromine, ethyl bromopyruvate, thiourea and ethanol are used as main raw materials, and a main factor affecting the product yield during cyclization reaction is the ratio of the important intermediate ethyl bromopyruvate to thethiourea. According to experimental procedures, the ethanol is selected as a solvent, nanocatalyst Cu2O@HKUST-1 is added, under reflux conditions, a desired product with a higher yield can be obtained by optimizing of the material ratio, the intermediate catalyst used in the method shortens the reaction cycle, a solid carbonate is used to adjust the pH of the reaction liquid, the generation of wastewater is reduced, and economic benefits are increased.
A pharmaceutical intermediates for synthesis and its preparation method (by machine translation)
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Paragraph 0041; 0042, (2017/11/04)
The present invention discloses a pharmaceutical intermediates for synthesis and its preparation method, its structural formula is as follows: Wherein R1 C is hydrogen or1 - C4 The alkane, R2 For C1 - C4 The alkane. The intermediate for the synthesis of 2 - isopropyl-thiazole - 4 - carboxylic acid ethyl ester, every one-step reaction conditions are easy to control, product yield and purity are very high, the operating procedure is simplified, basic does not need to be purified, and further reducing the cost of the final product. (by machine translation)
An efficient total synthesis of (-)-epothilone B
Wang, Jie,Sun, Bing-Feng,Cui, Kai,Lin, Guo-Qiang
supporting information, p. 6354 - 6357 (2013/02/23)
An efficient total synthesis of (-)-epothilone B has been achieved in ca. 8% yield over 11 steps from 9 (or 10 steps from 7/8), which features a bissiloxane-tethered ring closing metathesis reaction to approach the trisubstituted (Z) double bond and forms a new basis for further development of an industrial process for epothilone B and ixabepilone.