80-70-6Relevant articles and documents
Novel synthesis process of tetramethylguanidine
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Paragraph 0015-0017, (2021/06/12)
The invention belongs to the field of pharmaceutical chemicals, and particularly relates to a novel process for synthesizing a tetramethylguanidine product. The synthesis process of tetramethylguanidine comprises two main processes of chlorination reaction and condensation reaction, and the existing production process is an intermittent production process and is produced in batches. In the reaction process, an organic solvent needs to be used for extraction and purification for many times. The preparation process is complicated, the yield is low, the requirement on production equipment is high, the cost is high, and the safety and environmental protection are poor. The intermittent production process of tetramethylguanidine is continuously transformed, so that the yield is increased, and the safety, environmental friendliness and intelligence of the production line are improved; besides, the continuous transformation of the tetramethylguanidine production process has important practical significance.
Hydrogen bonding between solutes in solvents octan-1-ol and water
Abraham, Michael H.,Gola, Joelle M. R.,Cometto-Muniz, J. Enrique,Acree, William E.
experimental part, p. 7651 - 7658 (2011/02/25)
The 1:1 equilibrium constants, K, for the association of hydrogen bond bases and hydrogen bond acids have been determined by using octan-1-ol solvent at 298 K for 30 acid-base combinations. The values of K are much smaller than those found for aprotic, rather nonpolar solvents. It is shown that the log K values can satisfactorily be correlated against αH 2?βH2, where αH 2 and βH2 are the 1:1 hydrogen bond acidities and basicities of solutes. The slope of the plot, 2.938, is much smaller than those for log K values in the nonpolar organic solvents previously studied. An analysis of literature data on 1:1 hydrogen bonding in water yields a negative slope for a plot of log K against αH 2?βH2, thus showing how the use of very strong hydrogen bond acids and bases does not lead to larger values of log K for 1:1 hydrogen bonding in water. It is suggested that for simple 1:1 association between monofunctional solutes in water, log K cannot be larger than about -0.1 log units. Descriptors have been obtained for the complex between 2,2,2-trifluoroethanol and propanone, and used to analyze solvent effects on the two reactants, the complex, and the complexation constant.
Group(III)-metal-hydrides with a guanidino-type ligand
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Page column 3-4, (2008/06/13)
A compound of formula (I) wherein X is aluminium, gallium or indium; each Y, which may be the same or different, is nitrogen or phosphorus; R1and R2, which may be the same or different, are hydrogen, halogen or alkyl; and R3to R7, which may be the same or different, are hydrogen or a saturated group, or R3and R4, or R5and R6together represent a saturated divalent link thus completing a ring.