821-48-7Relevant articles and documents
Synthesis and fluorescent properties of a novel dansyl-based fluorescent probe for Hg2+
Zuo-An, Xiao,Dan, Zhan,Xiao, Yang
, p. 108 - 110 (2014)
A novel turn-off fluorescent probe containing a dansyl fluorophore has been synthesised. Its recognition properties towards various metal ions have been studied by fluorescence spectrometry. The compound showed a high sensitivity and selectivity to Hg2+ ion and a complexation ratio towards Hg 2+ of 2 : 1. Its fluorescence intensity varied almost linearly versus the concentration of Hg2+ (0.8-8.4 μmol L-1), and the detection limit of Hg2+ was estimated to be 0.88 μmol L -1.
Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents
Liu, Xiu-jie,Wang, Yan,Wang, Xiao,Zhang, Zhi-hao
, (2021/09/10)
In order to discover antiplatelet drug with novel structure and expand our research scope, total twenty 1,3-benzenedisulfonyl piperazines, were designed and synthesized. These target compounds were divided into two series, namely 4-methoxy-1,3-benzenedisulfonyl piperazines of series 1 and 4-ethoxy-1,3-benzenedisulfonyl piperazines of series 2. With adenosine diphosphate (ADP), arachidonic acid (AA) and collagen as inducers, respectively, the Born turbidimetric method was used to screen the antiplatelet activity in vitro of all target compounds at a concentration of 1.3 μM, with aspirin and picotamide as positive control drugs. And of which, the activities of five compounds for collagen were higher than both picotamide and aspirin. In ADP or AA channel, compounds with an inhibition rate greater than 33% were selected, and their corresponding IC50 values were obtained. According to the IC50, the in vitro activity of one compound for ADP was higher than picotamide, and for AA, two compounds were higher than two positive control drugs and other two compounds only higher than or equal to aspirin. The preliminary analysis of the structure-activity relationship of the target compounds involved in this study was completed. Further, eight compounds exhibiting higher activity in one or two test channels, were subjected to cytotoxicity test on mouse fibroblasts (L929) by CCK-8 method. The in vitro cytotoxicity of most test compounds showed less than or same to control drug picotamide at 10 μM, but at the higher concentration of 100 μM, merely two compounds exhibited higher cell survival rate than that of picotamide. In addition, compound N1,N3-di(4-ethoxy-1,3-phenylenedisulfonyl)bis(1-(m-tolyl)piperazine), which is delivery activity in the three test channels, and another compound N1,N3–di(4-methoxy-1,3-phenylenedisulfonyl)bis(1-(m-tolyl)piperazine), which has the lowest cytotoxic in vitro compound among series 1 and series 2, respectively, are found and selected for simulation analysis as two most likely to dock with the receptor P2Y12. Each of synthesized compounds in silico molecular property and ADME (absorption, distribution, metabolism and excretion) are predicted by using Molinspiration property engine v2018.10 and PreADMET online servers, respectively. Compared with other series of compounds in the previous stage, the two series compounds obtained after the introduction of piperazinyl have a similar in vitro activity.
Surface active SNS-based dicationic ionic liquids containing amphiphilic anions: Experimental and theoretical studies of their structures and organization in solution
Domingos, Josiel B.,Dupont, Jairton,Ferreira, Thuany M.,Monteiro, Wesley F.,Scholten, Jackson D.,Vieira, Michele O.,dos Santos, Francisco P.
, (2021/10/20)
Surface active ionic liquids (SAILs) have been reported as new media that collectively offer the advantages of the aqueous and oily phases. In particular, dicationic ionic liquids (DILs) have attracted much interests because their tunable physicochemical properties allow them to act as sustainable active catalysts in chemical reactions (CO2 conversion, esterification) and also as extraction media to remove drugs/pollutants from aqueous systems. In order to better understand this class of ILs, this work describes new strategies for the synthesis of SNS-based dicationic ILs containing amphiphilic anions ([C12SO4]-, [C12ESO4]-, [C12BSO3]- and [C12SAR]-) and the evaluation of their structural organization and aggregation level in solution. The results obtained by experimental techniques (FTIR, TGA, DSC, POM, ESI-MS, DLS and NMR) combined with those achieved by theoretical DFT calculations revealed that the anion has an important function to modulate the properties of the SNS-based ILs in solution, while the presence of a methyl group at the C2 position of the imidazolium ring seems to be not sufficient to change such physicochemical properties. The ILs containing the anion [C12BSO3]- showed a superior ionic organization in solution due to the cationic aggregates observed in the ESI(+) mode and the large size of aggregates observed by DLS. This behavior may be assigned to a close proximity of the cationic imidazolium ring and the aromatic ring in the anion (π-π interaction), and by NMR analysis (ROESY and DOSY) it was possible to confirm interactions between cation and anion. Therefore, the theoretical and experimental results obtained for the SNS-based dicationic ILs containing amphiphilic anions indicate that these ILs can be applied as media in both pure and/or solution systems for many sustainable applications.
