821-48-7Relevant articles and documents
Synthesis and fluorescent properties of a novel dansyl-based fluorescent probe for Hg2+
Zuo-An, Xiao,Dan, Zhan,Xiao, Yang
, p. 108 - 110 (2014)
A novel turn-off fluorescent probe containing a dansyl fluorophore has been synthesised. Its recognition properties towards various metal ions have been studied by fluorescence spectrometry. The compound showed a high sensitivity and selectivity to Hg2+ ion and a complexation ratio towards Hg 2+ of 2 : 1. Its fluorescence intensity varied almost linearly versus the concentration of Hg2+ (0.8-8.4 μmol L-1), and the detection limit of Hg2+ was estimated to be 0.88 μmol L -1.
Novel piperazine based compounds as potential inhibitors for SARS-CoV-2 Protease Enzyme: Synthesis and molecular docking study
El-atawy, Mohamed,El-sadany, Samer K.,Hamed, Ezzat A.,Mosa, Tawfik M.,Omar, Alaa Z.
, (2021/07/16)
Structurally diverse piperazine-based compounds hybrid with thiadiazole, isatin or with sulfur/nitrogen, functionalities were synthesized. The structures of the new compounds were established based on their spectral data and elemental analysis. The physicochemical, bioactivity scores and pharmacokinetic behavior of all the prepared ligands were evaluated using in silico computational tools. The new piperazine ligands have been screened for their inhibition activity against SARS-CoV-2 protease enzyme using molecular docking analysis. The docking studies showed that all the ligands have been docked with negative dock energy onto the target protease protein. Moreover, Molecular interaction studies revealed that SARS-CoV-2 protease enzyme had strong hydrogen bonding interactions with piperazine ligands. The present in silico study thus, provided some guidance to facilitate drug design targeting the SARS-CoV-2 main protease.
Synthesis, in vitro cytotoxicity and biological evaluation of twenty novel 1,3-benzenedisulfonyl piperazines as antiplatelet agents
Liu, Xiu-jie,Wang, Yan,Wang, Xiao,Zhang, Zhi-hao
, (2021/09/10)
In order to discover antiplatelet drug with novel structure and expand our research scope, total twenty 1,3-benzenedisulfonyl piperazines, were designed and synthesized. These target compounds were divided into two series, namely 4-methoxy-1,3-benzenedisulfonyl piperazines of series 1 and 4-ethoxy-1,3-benzenedisulfonyl piperazines of series 2. With adenosine diphosphate (ADP), arachidonic acid (AA) and collagen as inducers, respectively, the Born turbidimetric method was used to screen the antiplatelet activity in vitro of all target compounds at a concentration of 1.3 μM, with aspirin and picotamide as positive control drugs. And of which, the activities of five compounds for collagen were higher than both picotamide and aspirin. In ADP or AA channel, compounds with an inhibition rate greater than 33% were selected, and their corresponding IC50 values were obtained. According to the IC50, the in vitro activity of one compound for ADP was higher than picotamide, and for AA, two compounds were higher than two positive control drugs and other two compounds only higher than or equal to aspirin. The preliminary analysis of the structure-activity relationship of the target compounds involved in this study was completed. Further, eight compounds exhibiting higher activity in one or two test channels, were subjected to cytotoxicity test on mouse fibroblasts (L929) by CCK-8 method. The in vitro cytotoxicity of most test compounds showed less than or same to control drug picotamide at 10 μM, but at the higher concentration of 100 μM, merely two compounds exhibited higher cell survival rate than that of picotamide. In addition, compound N1,N3-di(4-ethoxy-1,3-phenylenedisulfonyl)bis(1-(m-tolyl)piperazine), which is delivery activity in the three test channels, and another compound N1,N3–di(4-methoxy-1,3-phenylenedisulfonyl)bis(1-(m-tolyl)piperazine), which has the lowest cytotoxic in vitro compound among series 1 and series 2, respectively, are found and selected for simulation analysis as two most likely to dock with the receptor P2Y12. Each of synthesized compounds in silico molecular property and ADME (absorption, distribution, metabolism and excretion) are predicted by using Molinspiration property engine v2018.10 and PreADMET online servers, respectively. Compared with other series of compounds in the previous stage, the two series compounds obtained after the introduction of piperazinyl have a similar in vitro activity.
Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition-Metal Catalysts
Oestreich, Martin,Seliger, Jan
supporting information, p. 247 - 251 (2020/10/29)
A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition-metal-catalyzed alcohol racemization and enantioselective Cu-H-catalyzed dehydrogenative Si-O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often-used ruthenium half-sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection.
Surface active SNS-based dicationic ionic liquids containing amphiphilic anions: Experimental and theoretical studies of their structures and organization in solution
Domingos, Josiel B.,Dupont, Jairton,Ferreira, Thuany M.,Monteiro, Wesley F.,Scholten, Jackson D.,Vieira, Michele O.,dos Santos, Francisco P.
, (2021/10/20)
Surface active ionic liquids (SAILs) have been reported as new media that collectively offer the advantages of the aqueous and oily phases. In particular, dicationic ionic liquids (DILs) have attracted much interests because their tunable physicochemical properties allow them to act as sustainable active catalysts in chemical reactions (CO2 conversion, esterification) and also as extraction media to remove drugs/pollutants from aqueous systems. In order to better understand this class of ILs, this work describes new strategies for the synthesis of SNS-based dicationic ILs containing amphiphilic anions ([C12SO4]-, [C12ESO4]-, [C12BSO3]- and [C12SAR]-) and the evaluation of their structural organization and aggregation level in solution. The results obtained by experimental techniques (FTIR, TGA, DSC, POM, ESI-MS, DLS and NMR) combined with those achieved by theoretical DFT calculations revealed that the anion has an important function to modulate the properties of the SNS-based ILs in solution, while the presence of a methyl group at the C2 position of the imidazolium ring seems to be not sufficient to change such physicochemical properties. The ILs containing the anion [C12BSO3]- showed a superior ionic organization in solution due to the cationic aggregates observed in the ESI(+) mode and the large size of aggregates observed by DLS. This behavior may be assigned to a close proximity of the cationic imidazolium ring and the aromatic ring in the anion (π-π interaction), and by NMR analysis (ROESY and DOSY) it was possible to confirm interactions between cation and anion. Therefore, the theoretical and experimental results obtained for the SNS-based dicationic ILs containing amphiphilic anions indicate that these ILs can be applied as media in both pure and/or solution systems for many sustainable applications.
RECYCLABLE CLEAN FRACTURING FLUID THICKENER, PREPARATION METHOD AND RECOVERY METHOD THEREOF, AND HIGH-TEMPERATURE RESISTANT CLEAN FRACTURING FLUID
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Paragraph 0051-0052, (2020/12/04)
Disclosed are a recyclable clean fracturing fluid thickener, a preparation method and a recovery method thereof, and a high-temperature resistant clean fracturing fluid, which relate to the stimulation treatment of oil and gas fields. Diethanolamine and thionyl chloride are used as raw materials and reacted to obtain an intermediate, which is then reacted with an unsaturated fatty acid amidopropyl dimethylamine to produce the recyclable clean fracturing fluid thickener. The clean fracturing fluid can be used in the fracturing stimulation treatment of low and medium permeability reservoirs.
Preparation method of 1-(2,3-dichlorophenyl)piperazine hydrochloride
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Paragraph 0011; 0012, (2019/06/08)
The invention belongs to the field of preparation of chemical intermediates, and particularly relates to a preparation method of 1-(2,3-dichlorophenyl)piperazine hydrochloride. The preparation methodcomprises the following steps of using diethanol amine as the initial raw material, and performing chlorination reaction, so as to obtain beta,beta'-dichlorodiethylamine hydrochloride; performing cyclization reaction with 2,3-dichloroaniline in a water solution under the condition of no catalyst, so as to synthesize a target compound, namely the 1-(2,3-dichlorophenyl)piperazine hydrochloride. Thepreparation method of the 1-(2,3-dichlorophenyl)piperazine hydrochloride has the advantages that the reaction rate is obviously accelerated, the yield rate is increased, and the cost is reduced.
Synthesis and Antitumor Effect of Sophoridine Derivatives Bearing an Acyclic Aryloxy Phosphoramidate Mustard Functionality
Dai, Lin-Lin,Li, Dong-Dong,Zhao, Xiu-Mei,Zhi, Shuang,Shen, Hong-Sheng,Yang, Zi-Bo
, p. 417 - 425 (2018/12/05)
To elevate the potency of sophoridine, phosphoramidate mustard motif was incorporated to D-ring opened sophoridine scaffold. A series of acyclic aryloxy phosphoramidate mustard functionalized sophoridine derivatives were synthesized and screened for cytostatic activity in a range of different tumor cell lines (S180, H22, K562, MCF-7, SMMC-7721, and LoVo). All these compounds were shown to be more sensitive to S180 and H22 cells with IC50 values ranging from 2.10 to 7.21?μM. In addition, all targeted derivatives distinctly are more cytotoxic to cancer cells than normal cell L929. Compounds 8b, 8c, 8d, and 8e displayed moderate tumor suppression without apparent organ toxicity in vivo against mice bearing H22 liver tumors. Their potential binding modes with DNA topoisomerase I complex have also been investigated.
Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands
Zhou, Benhua,Hong, Kwon Ho,Ji, Min,Cai, Jin
, p. 1597 - 1609 (2018/07/31)
Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.
Synthesis of novel perfluoroalkyl ether derivatives
Shi, Xiang,Shi, Hongxin,Wu, Hongke,Shen, HaiMin
, p. 5091 - 5105 (2018/04/05)
A series of novel fluoroether-containing monomers has been designed and prepared based on the commercially available perfluoroalkyl ether acid fluoride. Treating acid fluoride with allyl alcohol, 2-hydroxyethyl methacrylate or N-allylmethylamine allowed for the direct formation of corresponding vinyl-containing fluorinated monomers. High yields of the fluorinated epoxy monomers could be obtained from acid chloride with glycidol; meanwhile, fluorinated diol was prepared from diethanolamine or 3-amino-1,2-propanediol. Moreover, fluorinated monoamine, fluorinated monoalcohol and fluorinated dichloride were also obtained. Most of these fluorinated monomers were liquid at room temperature and exhibited good solubility in common organic solvents.
