Organic Process Research and Development p. 86 - 89 (2007)
Update date:2022-09-26
Topics:
Kanamarlapudi, Ramanaiah C.
Bednarz, Mark
Wu, Wenxue
Keyes, Philip
An efficient and environmentally benign synthesis of 5-methyl-3H-pyrrolo[2, 3-d]pyrimidin-4(7H)-one is described. An acyl-protected aminoacetone is reacted with cyanoacetamide to give 2-amino-4-methyl-1H-pyrrole-3-carboxamide, which is converted in one-pot to 5-methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one in 60% overall yield. This process avoids the use of large excess Raney nickel which is required when known methods are practiced.
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