Synthetic Studies Directed toward the Naturally Occurring Acyl Tetramic Acids. 1. Covergent Total Synthesis of (+/-)-Tirandamycin A

Article abstract of DOI:10.1021/ja00278a031

An efficient convergent synthetic approach to the structurally unusual tetramic acid antibiotic tirandamycin A is described.Among the key features is the use of a rigid substituted cyclohexanone derivative as a vehicle to assure control of the relative st