Chemical and Pharmaceutical Bulletin p. 2568 - 2571 (1992)
Update date:2022-08-03
Topics:
Nakai
Sasai
Ezawa
The stability of 5'-deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine (Ro 09-1390) in buffered solutions at 37 °C was studied. Seven degradation products were identified by high-performance liquid chromatography (HPLC) and spectroscopy. The degradation products were different depending on the pH of the solution. Ro 09-1390 was unstable at pH 2.1 and stable at around pH 5.6 in spite of forming several decomposition products; and its degradation rate did not change in the pH range from 8 to 12. The degradation of Ro 09-1390 followed apparent first order kinetics and the decomposition pathway at alkaline conditions was different from the one at acidic conditions. On the other hand, at neutral pH the other decomposition products were formed.
View MoreShangyu Sanhechemicals Co.,LTD.
Contact:86-0571-56696839
Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China
Shenzhen ZheYi Chemicals Co.,LTD(Shanghai Branch)
Contact:+86-21-54159691
Address:Room1002,Building No.2, Lane 98 Bixiu Road,Minhang District, Shanghai,China 201100
Kaiping Genuine Biochemical Pharmaceutical Co.,Ltd.
Contact:+86-750-2881198
Address:No.1, Xinke Road, Shatang Town, Kaiping, Guangdong Province, P.R.China
Jiangsu Jiuri Chemical Co.,Ltd.
Contact:+86-519-82118868
Address:Tianwang Town, Jurong City, Jiangsu Province, China
Contact:+86-535-8888888
Address:No.161 Haishi Rd.
Doi:10.1002/ardp.19863191005
(1986)Doi:10.1021/jm8002763
(2008)Doi:10.1021/jo00382a007
(1987)Doi:10.1021/ja805128x
(2008)Doi:10.1021/acs.orglett.0c03879
(2021)Doi:10.1021/jo00383a018
(1987)
