Stability and degradation kinetics of 5'-deoxy-5-fluoro-N4-(3,4,5-trimethoxybenzoyl)cytidine in aqueous solution

Article abstract of DOI:10.1248/cpb.40.2568

The stability of 5'-deoxy-5-fluoro-N⁴-(3,4,5-trimethoxybenzoyl)cytidine (Ro 09-1390) in buffered solutions at 37 °C was studied. Seven degradation products were identified by high-performance liquid chromatography (HPLC) and spectroscopy. The degradation products were different depending on the pH of the solution. Ro 09-1390 was unstable at pH 2.1 and stable at around pH 5.6 in spite of forming several decomposition products; and its degradation rate did not change in the pH range from 8 to 12. The degradation of Ro 09-1390 followed apparent first order kinetics and the decomposition pathway at alkaline conditions was different from the one at acidic conditions. On the other hand, at neutral pH the other decomposition products were formed.

Full text of DOI:10.1248/cpb.40.2568

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service

NII-Electronic Library Service