Archiv der Pharmazie p. 554 - 561 (2008)
Update date:2022-08-04
Topics:
Suzuki, Yamato
Cluzeau, Jerome
Hara, Takafumi
Hirasawa, Akira
Tsujimoto, Gozoh
Oishi, Shinya
Ohno, Hiroaki
Fujii, Nobutaka
Structually related to the known CK2 inhibitors, 2,6-disubstituted pyrazine and 4,6-disubstituted pyrimidine derivatives were synthesized and their inhibitory activities toward CK2α and CK2α′ were evaluated. Structure-activity relationship study has revealed that several pyrazine derivatives bearing a (pyrrol-3-yl)acetic acid and a monosubstituted aniline possess potent inhibitory activities.
Chengdu Chengnuo New-Tech Co., Ltd
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Changsha Huajing Powdery Material Technological Co., Ltd.
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ALPHA PHARMACEUTICAL CO，LTD JIANGSU
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Nanjing Capatue Chemical Co., Ltd
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Address:No.20 Jiangjun Avenue, Jiangning Economic & Technical Development Zone
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(1986)Doi:10.1007/BF00954840
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(2011)Doi:10.1021/jo00388a042
(1987)Doi:10.1248/cpb.34.2435
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