Synthesis of Functionalized Bicyclic Dioxopiperazines via Intramolecular Epoxide Opening

DOI: 10.1021/jo00227a019

Source and publish data:

Journal of Organic Chemistry p. 4044 - 4047 (1987)

Update date:2022-08-03

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Authors:

Williams, Robert M.

Maruyama, Lynn K.

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Article abstract of DOI:10.1021/jo00227a019

d,l-Homoserine was condensed with N-p-methoxybenzylglycine ethyl ester and alkylated to furnish (2-hydroxyethyl)piperazinedione 8.Oxidation to the correspomding aldehyde and condensation with dimethylsulfoxonium methylide provided the epoxide 10.Enolate f

Full text of DOI:10.1021/jo00227a019

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