SYNTHESIS OF SUBSTITUTED THIENOTHIAZOLES AND INDOLOTHIAZOLES

Article abstract of DOI:10.1007/BF00761998

Alkylene-, halo-, and aryl-substituted 2-methylthieno<2,3-d>thiazoles were obtained by the action of phosphorus pentasulfide on the corresponding 2-acetylamino-3-bromo- or 2-acetylamino-3-hydroxythiophenes in an organic solvent with heating. 2-Oximes of halo- and methyl-substituted isatins were converted by reduction and acetylation into 2-hydroxy-3-acetylaminoindoles, from which 2-methylindolo<3,2-d>-thiazoles were obtained by the action of phosphorous pentasulfide with heating in xylene.