Syntheses and Separations of Diastereomers of Protected-Δ1-, Δ2-, and Δ3-Dehydrotripeptides

Article abstract of DOI:10.1246/cl.1988.1469

Total eighteen kinds of Δ¹-, Δ²-, and Δ³-dehydrotripeptides (DHP) containing of a ΔPhe and two chiral α-amino acid residues were synthesized and the diastereomeric mixture of DHP were subjected to the HPLC separation.From the results and the ¹H NMR spectral data, it was found to be significant relationship between the separation and the conformational structure of DHP.