Studies Relating to the Synthesis of Immunosuppressive Agent FK-506: Synthesis of the Cyclohexyl Moiety via a Group-Selective Epoxidation

Article abstract of DOI:10.1021/jo00262a004

The asymmetric synthesis of the cyclohexyl moiety of FK-506 is reported.The absolute stereogenicity of the target subunit was derived from the catalytic asymmetric synthesis of an epoxide by the method of Sharpless.