European Journal of Medicinal Chemistry p. 473 - 478 (1987)
Update date:2022-08-02
Topics:
Bellucci, Christina
Gualtieri, Fulvio
Chiarini, Alberto
Several para-substituted diethyl benzylphosphonates related to the calcium antagonist diethyl 4-(2-benzothiazolyl)benzylphosphonate (fostedil) have been studied.They produce a dose-dependent negative inotropic effect on left atrial muscle isolated from guinea pig heart.Some of the compounds are equipotent or slightly more potent than fostedil and diltiazem taken as reference drugs.Structure-activity relationships are discussed.Keywords: calcium antagonists / p-substituted diethyl benzylphosphonates / cardiodepressant activity
View MoreHefei Highzone Fine Chemical S&T CO.,LTD
Contact:86-0551-63663560
Address:room 1801 NO. 24 Shuguang RD.
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
Taizhou KEDE Chemical.Co.,Ltd.
Contact:86-576-84613060
Address:Jiangkou Chemical Zoon
Contact:+33-5-34012600
Address:28 ZA des Pignès
Contact:0833-5590788/5590338/5590055
Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
Doi:10.1002/chem.201403514
(2014)Doi:10.1002/ejoc.201500330
(2015)Doi:10.1055/s-1988-27638
(1988)Doi:10.1021/jo00265a034
(1989)Doi:10.1021/jo502467m
(2015)Doi:10.1016/j.tetlet.2008.07.055
(2008)
