European Journal of Medicinal Chemistry p. 473 - 478 (1987)
Update date:2022-08-02
Topics:
Bellucci, Christina
Gualtieri, Fulvio
Chiarini, Alberto
Several para-substituted diethyl benzylphosphonates related to the calcium antagonist diethyl 4-(2-benzothiazolyl)benzylphosphonate (fostedil) have been studied.They produce a dose-dependent negative inotropic effect on left atrial muscle isolated from guinea pig heart.Some of the compounds are equipotent or slightly more potent than fostedil and diltiazem taken as reference drugs.Structure-activity relationships are discussed.Keywords: calcium antagonists / p-substituted diethyl benzylphosphonates / cardiodepressant activity
View MoreMelone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
website:http://www.tbbmed.com
Contact:86--21-50498136
Address:Room 6002, Building 7-1, No.160 Basheng Road,Pudong Area,Shanghai China
Jurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Contact:021-36356756
Address:Room601,Building No.14,280 Yangcheng Road,Shanghai
Jintan Jinnuo Chemical Co., Ltd.
Contact:+86-519-80199901
Address:Room 1804, Building 1, Huacheng Business Plaza, Jintan, Jiangsu, China
Doi:10.1002/chem.201403514
(2014)Doi:10.1002/ejoc.201500330
(2015)Doi:10.1055/s-1988-27638
(1988)Doi:10.1021/jo00265a034
(1989)Doi:10.1021/jo502467m
(2015)Doi:10.1016/j.tetlet.2008.07.055
(2008)
