TOTAL SYNTHESIS OF 5(S),12(S)- AND 5(S),12(R)-DIHYDROXYEICOSA-6(Z),8(E),14(Z)-TRIENOIC ACIDS, METABOLITES OF LEUKOTRIENE B4

DOI: 10.1016/S0040-4039(00)95219-5

Source and publish data:

Tetrahedron Letters p. 429 - 432 (1989)

Update date:2022-09-26

Topics: Stereochemistry Total synthesis Starting Materials Metabolite

Authors:

Yadagiri, Pendri

Lumin, Sun

Falck, J. R.

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Article abstract of DOI:10.1016/S0040-4039(00)95219-5

The recently identified dihydro-leukotriene B₄ metabolite 1 and its C(12)-epi analogue 2 were prepared by Wittig coupling of segments derived from 2-deoxy-D-ribose and L-glutamic acid.

Full text of DOI:10.1016/S0040-4039(00)95219-5

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Product name:(6Z,8E,14Z)-(5S,12R)-5,12-Dihydroxy-icosa-6,8,14-trienoic acid

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