Synthesis, Conformation, and Immunosuppressive Activities of Three Analogues of Cyclosporin A Modified in the 1-Position

DOI: 10.1021/jm00165a018

Source and publish data:

Journal of Medicinal Chemistry p. 999 - 1009 (1990)

Update date:2022-08-02

Topics:

Authors:

Aebi, Johannes D.

Deyo, Donald T.

Sun, Chong Qing

Guillaume, Dominique

Dunlap, Brian

Rich, Daniel H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00165a018

The syntheses of three new cyclosporin A (CsA) analogues that contain novel MeBmt derivatives in the 1-position are described.The MeBmt analogue that contains an additional methyl group on C4, (2S,3R,6E)-4,4-dimethyl-3-hydroxy-2-(N-methylamino)-6-octenoic

Full text of DOI:10.1021/jm00165a018

Products guided by the article

Product name:<(9-fluorenylmethyl)oxycarbonyl>-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl<(2S,3R,6E)-3-hydroxy-2-(methylamino)-6-octenoyl>-L-2-aminobutyryl-sarcosyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanine benzyl ester

Cas No:124562-31-8

R&D Labs maybe for 124562-31-8

Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
Zhejiang Newfine Industry Co.,Ltd.

Contact:+86-573-82262042

Address:No.225,Dongqing Road, garoms@163.com
Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province
shanghai jiuling chemical co.,ltd.

Contact:+86-21-50387295

Address:Zaozhuang Road, Pudong, Shanghai City. China
Beijing Wisdom Chemicals Co., Ltd.

Contact:+86-10-52350335

Address:F2, BLDG 19, Liando Valley U, Majuqiao, Tongzhou District, Beijing, China

Relevant to this article

The [2 + 4] Diels-Alder cycloadditon product of a probable dialuminene, Ar′AlAlAr′ (Ar′ = C₆H₃- 2,6-Dipp ₂; Dipp = C₆H₃-2,6-Prⁱ₂), with toluene

Doi:10.1021/ja034478p
(2003)
Base-Catalyzed Acyl Exchange Reactions of N,O-Diacyl-o-aminophenols. Substituent and Temperature Effects on the Equilibrium Constants

Doi:10.1246/bcsj.69.775
(1996)
Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid

Doi:10.1016/S0960-894X(03)00545-6
(2003)
Azomethine Ylides from Nitrones: Using Catalytic nBuLi for the Totally Stereoselective Synthesis of trans-2-Alkyl-3-oxazolines

Doi:10.1002/chem.201602159
(2016)
Comparative Studies of the Formation of Surface Relief Grating. Amorphous Molecular Material vs Vinyl Polymer

Doi:10.1246/cl.2003.710
(2003)
Neuroleptics of the 10 piperazino 10,11 dihydrodibenzo[b,f] thiepin series and related substances: piperazine alkylated homologues of octoclothepin and methiothepin; 5,5 dimethyl 10,11 dihydro 5H dibenzo[b,f] silepin analogue of perathiepin

Doi:10.1135/cccc19760910
(1976)

Article Doi