Synthesis, Conformation, and Immunosuppressive Activities of Three Analogues of Cyclosporin A Modified in the 1-Position

DOI: 10.1021/jm00165a018

Source and publish data:

Journal of Medicinal Chemistry p. 999 - 1009 (1990)

Update date:2022-08-02

Topics:

Authors:

Aebi, Johannes D.

Deyo, Donald T.

Sun, Chong Qing

Guillaume, Dominique

Dunlap, Brian

Rich, Daniel H.

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Article abstract of DOI:10.1021/jm00165a018

The syntheses of three new cyclosporin A (CsA) analogues that contain novel MeBmt derivatives in the 1-position are described.The MeBmt analogue that contains an additional methyl group on C4, (2S,3R,6E)-4,4-dimethyl-3-hydroxy-2-(N-methylamino)-6-octenoic

Full text of DOI:10.1021/jm00165a018

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