Stereocontrolled Synthesis of Andrimid and a Structural Requirement for the Activity

DOI: 10.1039/c39890000299

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 299 - 301 (1989)

Update date:2022-08-04

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Authors:

McWhorter, William

Fredenhagen, Andreas

Nakanishi, Koji

Komura, Hajime

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Article abstract of DOI:10.1039/c39890000299

Total synthesis of an antibiotic Andrimid was accomplished stereospecifically: it was shown that the chiralities at C-3 and C-4 should be R and S, respectively, and the presence of the (4S)-methyl group is important for the activity.

Full text of DOI:10.1039/c39890000299

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