Asymmetric Reduction of 2-Fluoro-2-(trifluoromethyl)-3-hydroxy Ketones with Lithium Aluminum Hydride or Diisobutylaluminum Hydride. Highly Stereoselective Synthesis of 2-Fluoro-2-(trifluoromethyl)-1,3-diols

DOI: 10.1016/S0040-4039(00)77080-8

Source and publish data:

Tetrahedron Letters p. 5263 - 5266 (1994)

Update date:2022-08-02

Topics:

Authors:

Ishihara, Takashi

Yamaguchi, Koichi

Kuroboshi, Manabu

Utimoto, Kiitiro

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Article abstract of DOI:10.1016/S0040-4039(00)77080-8

The syn and anti isomers of 2-fluoro-2-(trifluoromethyl)-3-hydroxy ketones are reduced in a highly 1,2-syn diastereoselective manner with lithium aluminum hydride or diisobutylaluminum hydride in tetrahydrofuran at -78 degC, affording 1,2-syn-2,3-syn- and

Full text of DOI:10.1016/S0040-4039(00)77080-8

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