Cyclohexane Diester Analogues of Phorbol Ester as Potential Activators of Protein Kinase C

DOI: 10.1021/jm00169a023

Source and publish data:

Journal of Medicinal Chemistry p. 1958 - 1962 (1990)

Update date:2022-08-04

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Authors:

Kerr, David E.

Kissinger, Lon F.

Shoyab, Mohammed

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Article abstract of DOI:10.1021/jm00169a023

Phospholipid-dependent, Ca²⁺-sensitive protein kinase (protein kinase C) is activated by the plant product phorbol ester at nanomolar concentrations and also in vivo at micromolar concentrations by diacylglycerols.We designed and synthesized cy

Full text of DOI:10.1021/jm00169a023

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