Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy

Article abstract of DOI:10.1016/j.bmcl.2017.03.090

The involvement of the phosphoinositide 3-kinases (PI3Ks) in several diseases, especially in the oncology area, has singled it as one of the most explored therapeutic targets in the last two decades. Many different inhibitor classes have been developed by

Full text of DOI:10.1016/j.bmcl.2017.03.090

Accepted Manuscript
Generation of Tricyclic Imidazo[1,2-a]pyrazines as novel PI3K inhibitors by
Application of a Conformational Restriction Strategy
Sonia Martínez González, Sonsoles Rodríguez-Arístegui, Ana Isabel
Hernández, Carmen Varela, Esther González Cantalapiedra, Rosa María
Álvarez, Antonio Rodríguez Hergueta, James R. Bischoff, María Isabel
Albarrán, Antonio Cebriá, Elena Cendón, David Cebrián, Patricia Alfonso,
Joaquín Pastor
PII:
S0960-894X(17)30340-2
DOI:
http://dx.doi.org/10.1016/j.bmcl.2017.03.090
BMCL 24842
Reference:
Bioorganic & Medicinal Chemistry Letters
To appear in:
Received Date:
Revised Date:
Accepted Date:
9 March 2017
28 March 2017
29 March 2017
Please cite this article as: González, S.M., Rodríguez-Arístegui, S., Isabel Hernández, A., Varela, C., Cantalapiedra,
E.G., María Álvarez, R., Hergueta, A.R., Bischoff, J.R., Isabel Albarrán, M., Cebriá, A., Cendón, E., Cebrián, D.,
Alfonso, P., Pastor, J., Generation of Tricyclic Imidazo[1,2-a]pyrazines as novel PI3K inhibitors by Application of
a Conformational Restriction Strategy, Bioorganic & Medicinal Chemistry Letters (2017), doi: http://dx.doi.org/
10.1016/j.bmcl.2017.03.090
This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers
we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and
review of the resulting proof before it is published in its final form. Please note that during the production process
errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.