STEREOSPECIFIC C-C-BOND FORMATION WITH RABBIT MUSCLE ALDOLASE - A CHEMOENZYMATIC SYNTHESIS OF (+)-EXO-BREVICOMIN

Article abstract of DOI:10.1016/S0040-4039(00)94649-5

(+)-(1S,5R,7S)-Exo-brevicomin 9, a sex pheromone of the western pine bark beetle, is synthesized using an aldol reaction catalyzed by fructose-1,6-diphosphate aldolase (EC 4.1.2.13) from rabbit muscle as the key step by which the absolute configuration of the target is established.