Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues

DOI: 10.1021/jm00106a021

Source and publish data:

Journal of Medicinal Chemistry p. 606 - 610 (1991)

Update date:2022-08-02

Topics:

Authors:

Singh Singh

Dev Dev

Duch Duch

Ferone Ferone

Smith Smith

Freisheim

Hynes Hynes

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00106a021

Prompted by recent disclosures concerning the potent antitumor activities of 5-deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), we have prepared 5-deazaisofolic acid (3a) and 5-deaza-5,6,7,8-tetrahydroisofolic aci

Full text of DOI:10.1021/jm00106a021

Products guided by the article

Product name:di-tert-butyl 5-deazaisofolate

Cas No:130327-75-2

R&D Labs maybe for 130327-75-2

Shandong Yaroma Perfumery Co., Ltd.

Contact:+86- 531- 88024598

Address:7-702 Caizhi Central, 59 Gong Ye South Road, Jinan City,250101, P. R. China
Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
ShangHai BMG Chemical Co., Ltd

Contact:+86-13524845543

Address:Room 602, no 291 sikai road shanghai
Beijing Tianjia Chemical Science & Technology Co.,Ltd

Contact:86-0550-2392698

Address:No.388, Shiliang Road (East),
QINGDAO DEVELOP chemistry Co.,Limited

Contact:+86-532-85807910

Address:98#Nanjing Road, Qingdao, China 266071

Relevant to this article

Fluorinated cyclopropanes: Synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

Doi:10.1039/c8cc04964e
(2018)
Indole-based hydrazones containing a sulfonamide moiety as selective inhibitors of tumor-associated human carbonic anhydrase isoforms ix and xii

Doi:10.3390/ijms20092354
(2019)
Asymmetric Synthesis of β-Amino Acid Derivatives by Michael Addition to Chiral 2-Aminomethylacrylates

Doi:10.1016/S0040-4039(00)91786-6
(1993)
Doi:10.1021/jm00302a010
(1969)
13C AND 19F NMR SPECTROSCOPIC STUDY OF SUBSTITUENT EFFECTS IN α,α-DIFLUOROARYLCARBENIUM IONS

Doi:10.1016/S0022-1139(00)80361-9
(1990)
Alkylation of 3,4-dihydro-β-carboline

Doi:10.1248/cpb.41.287
(1993)

Article Doi