Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues

DOI: 10.1021/jm00106a021

Source and publish data:

Journal of Medicinal Chemistry p. 606 - 610 (1991)

Update date:2022-08-02

Topics:

Authors:

Singh Singh

Dev Dev

Duch Duch

Ferone Ferone

Smith Smith

Freisheim

Hynes Hynes

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Article abstract of DOI:10.1021/jm00106a021

Prompted by recent disclosures concerning the potent antitumor activities of 5-deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), we have prepared 5-deazaisofolic acid (3a) and 5-deaza-5,6,7,8-tetrahydroisofolic aci

Full text of DOI:10.1021/jm00106a021

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