Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues

DOI: 10.1021/jm00106a021

Source and publish data:

Journal of Medicinal Chemistry p. 606 - 610 (1991)

Update date:2022-08-02

Topics:

Authors:

Singh Singh

Dev Dev

Duch Duch

Ferone Ferone

Smith Smith

Freisheim

Hynes Hynes

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00106a021

Prompted by recent disclosures concerning the potent antitumor activities of 5-deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), we have prepared 5-deazaisofolic acid (3a) and 5-deaza-5,6,7,8-tetrahydroisofolic aci

Full text of DOI:10.1021/jm00106a021

Products guided by the article

Product name:di-tert-butyl 5-deazaisofolate

Cas No:130327-75-2

R&D Labs maybe for 130327-75-2

Suzhou Howsine Biological Technology Co.,Ltd(expird)

website:http://www.howsine.com

Contact:86-512-67262751

Address:No 3,Weihua Road ,Suzhou Industrial Park ,Jiangsu ,China.
Shandong Loyal Chemical industrial Co.,Ltd

Contact:0533-7451788

Address:Linzi Chemical Industrial Park, Zibo, Shandong Province
Shanghai Surseechem Co.,Ltd.

Contact:+86-21-61318535

Address:Building 29,No.2139 Xizha Road, Fengxian District, Shanghai
HangZhou HuaYe Chemical Technology Co.,Ltd

Contact:+86-13505815007

Address:hangzhou
Changzhou Welton Chemical Co., Ltd,

Contact:0086-519-85910828,85920537,85912897

Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.

Relevant to this article

Fluorinated cyclopropanes: Synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

Doi:10.1039/c8cc04964e
(2018)
Indole-based hydrazones containing a sulfonamide moiety as selective inhibitors of tumor-associated human carbonic anhydrase isoforms ix and xii

Doi:10.3390/ijms20092354
(2019)
Asymmetric Synthesis of β-Amino Acid Derivatives by Michael Addition to Chiral 2-Aminomethylacrylates

Doi:10.1016/S0040-4039(00)91786-6
(1993)
Doi:10.1021/jm00302a010
(1969)
13C AND 19F NMR SPECTROSCOPIC STUDY OF SUBSTITUENT EFFECTS IN α,α-DIFLUOROARYLCARBENIUM IONS

Doi:10.1016/S0022-1139(00)80361-9
(1990)
Alkylation of 3,4-dihydro-β-carboline

Doi:10.1248/cpb.41.287
(1993)

Article Doi