Chemistry - A European Journal p. 5403 - 5408 (2014)
Update date:2022-08-04
Topics:
Li, Jie
John, Michael
Ackermann, Lutz
Cationic ruthenium complexes derived from KPF6 or AgOAc enabled efficient oxidative C-H functionalizations on aryl and heteroaryl amidines. Thus, oxidative annulations of diversely decorated internal alkynes provided expedient access to 1-aminoisoquinolines, while catalyzed C-H activations with substituted acrylates gave rise to structurally novel 1-iminoisoindolines. The powerful ruthenium(II) catalysts displayed a remarkably high site-, regio- and, chemoselectivity. Therefore, the catalytic system proved tolerant of a variety of important electrophilic functional groups. Detailed mechanistic studies provided strong support for the cationic ruthenium(II) catalysts to operate by a facile, reversible C-H activation. Ring road: Cationic ruthenium(II) complexes allowed for efficient C-H activation on (hetero)aryl amidines with alkynes and alkenes, thereby providing a step-economical access to diversely decorated isoquinolines and isoindolines, respectively (see scheme).
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