Chemical and Pharmaceutical Bulletin p. 758 - 762 (1993)
Update date:2022-07-29
Topics:
Kume
Kubota
Kimura
Nakashimizu
Motokawa
The synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylic acids with various C-7 side chains (2) are described. The (1H-1,2,3-triazol-4-yl)thiomethylthio C-3 side chain was found to be an effective substituent for good oral absorption of cephalosporins with some C-7 side chains.
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