Orally active cephalosporins. IV. Synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-cephalosporins

DOI: 10.1248/cpb.41.758

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 758 - 762 (1993)

Update date:2022-07-29

Topics:

Authors:

Kume Kume

Kubota Kubota

Kimura Kimura

Nakashimizu

Motokawa

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Article abstract of DOI:10.1248/cpb.41.758

The synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylic acids with various C-7 side chains (2) are described. The (1H-1,2,3-triazol-4-yl)thiomethylthio C-3 side chain was found to be an effective substituent for good oral absorption of cephalosporins with some C-7 side chains.

Full text of DOI:10.1248/cpb.41.758

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Product name:diphenylmethyl 7β-phenylacetamido-3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylate

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