Orally active cephalosporins. IV. Synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-cephalosporins

DOI: 10.1248/cpb.41.758

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 758 - 762 (1993)

Update date:2022-07-29

Topics:

Authors:

Kume Kume

Kubota Kubota

Kimura Kimura

Nakashimizu

Motokawa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.41.758

The synthesis, antibacterial activity and oral absorption of 3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylic acids with various C-7 side chains (2) are described. The (1H-1,2,3-triazol-4-yl)thiomethylthio C-3 side chain was found to be an effective substituent for good oral absorption of cephalosporins with some C-7 side chains.

Full text of DOI:10.1248/cpb.41.758

NII-Electronic Library Service

Products guided by the article

Product name:diphenylmethyl 7β-phenylacetamido-3-(1H-1,2,3-triazol-4-yl)thiomethylthio-3-cephem-4-carboxylate

Cas No:140128-30-9

R&D Labs maybe for 140128-30-9

Cerametek Materials（ShenZhen）Co., Ltd.

Contact:+86-755-2324.2554

Address:A3-#9, YongChuan Street, Suite 501
Jintan City Mego Chemical Co., Ltd

Contact:+86-0519-82814387

Address:23# Dengguan Town, Jintan, Jiangsu Province, China
DU-HOPE INTERNATIONAL GROUP

Contact:+86-25-52346955

Address:199,JIANYE ROAD,NANJING,CHINA
Jiande City Silibase Silicone New Material Manufacture Co., Ltd.

Contact:15967177856

Address:Genglou Industrial Development Area
Anhui Jiatiansen Agrochemical Co.,Ltd

Contact:15366811918

Address:chemical industrial park,xiangyu town,dongzhi county,anhui,china

Relevant to this article

Switchable stereoselectivity: The effects of substituents on the D ₂-symmetric biphenyl backbone of phosphoramidites in copper-catalyzed asymmetric conjugate addition reactions with triethylaluminium

Doi:10.1002/adsc.201101007
(2012)
Preparation of Ag-doped g-C₃N₄ Nano Sheet Decorated Magnetic γ-Fe₂O₃@SiO₂ Core–Shell Hollow Spheres through a Novel Hydrothermal Procedure: Investigation of the Catalytic activity for A³, KA² Coupling Reactions and [3?+?2] Cycloaddition

Doi:10.1002/aoc.4413
(2018)
Practical oxidative homo- and heterocoupling of terminal alkynes catalyzed by immobilized copper in MCM-41

Doi:10.1002/ejoc.201200359
(2012)
Assessing biocatalysis for the synthesis of optically active tetrahydropyrazolo[1,5-α]pyrimidines (THPPs) as novel therapeutic agents

Doi:10.1016/j.molcatb.2013.11.012
(2014)
n-Pentenyl Esters Facilitate and Oxidative Alternative to the Ferrier Rearrangement. An Expeditious Route to Sucrose

Doi:10.1039/c39920000094
(1992)
Synthesis of substances related to Fluticasone propionate

Doi:10.1080/00304940809458122
(2008)

Article Doi