Simple Spectrophotometric Method for Determination of Carbonyl and Sulfonyl Chlorides

Article abstract of DOI:10.1021/ac00278a059

The method presented is based on the reaction of carbonyl and sulfonyl chlorides with sodium azide in water-acetone solution at room temperature for 10 min; the excess of azide is determined spectrophotometrically after conversion to a red complex with Fe³⁺.Reactive anhydride can also be determined by this method.The application of the new method was demonstrated for monitoring conversion of sulfonyl chlorides to sulfonyl fluorides and for controlling the acylation of amino compounds with phthaloyl-L-glutamic anhydride.