An efficient and scalable synthesis of arabinosylguanine and 2′-deoxy-2′-fluoro-guanosine

Article abstract of DOI:10.1080/07328319708006246

An efficient conversion from commercially available 2,6-diaminopurine-2′,3′,5′-tri-O-benzyl arabinoside to arabinosylguanine and its further transformation to 2′-deoxy-2′-fluoro-guanosine is outlined. This process has been used to produce more than one hundred grams of final product. Copyright

Full text of DOI:10.1080/07328319708006246

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Nucleosides and Nucleotides
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An Efficient and Scalable Synthesis of
Arabinosylguanine and 2′-Deoxy-2′-
Fluoro-guanosine
Bruce S. Ross a , Robert H. Springer a , Kelly G. Sprankle a &
Guillermo Vasquez a
a Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, CA,
92008
Available online: 16 Aug 2006
To cite this article: Bruce S. Ross, Robert H. Springer, Kelly G. Sprankle & Guillermo Vasquez
(1997): An Efficient and Scalable Synthesis of Arabinosylguanine and 2′-Deoxy-2′-Fluoro-
guanosine, Nucleosides and Nucleotides, 16:7-9, 1645-1647
To link to this article: http://dx.doi.org/10.1080/07328319708006246
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