Asymmetric syntheses of protected derivatives of carnosadine and its stereoisomers as conformationally constrained surrogates for arginine

Article abstract of DOI:10.1021/jo00087a039

All four stereoisomers of carnosadine were shown to be accessible from the lactone 1 or the diester 10 (or their enantiomers). Members of the cis series (Z-cyclo-Arg') were obtained via a sequence involving opening lactone 1 with ammonia, Hofmann rearrang