Syntheses of conformationally restricted analogues of an angiotensin II receptor antagonist. General synthetic approach to functionalized imidazo[1,5-a]pyridine derivatives

DOI: 10.1016/S0040-4039(00)78550-9

Source and publish data:

Tetrahedron Letters p. 9391 - 9394 (1994)

Update date:2022-07-30

Topics:

Authors:

Musicki, Branislav

Vevert, Jean-Paul

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)78550-9

Syntheses of two conformationally restricted analogues 3 and 4 of the angiotensin II receptor antagonists losartan (1) are described. Michael addition of imidazole-5-carboxaldehyde 8 to biphenylpropiolate 7 provides an efficient method for the skeletal construction of imidazo[1,5-α]pyridine derivatives.

Full text of DOI:10.1016/S0040-4039(00)78550-9

Products guided by the article

Product name:3-(2-Butyl-4-chloro-5-hydroxymethyl-imidazol-1-yl)-3-(2'-cyano-biphenyl-4-yl)-propionic acid ethyl ester

Cas No:161196-54-9

R&D Labs maybe for 161196-54-9

Changsha Goomoo Chemical Technology Co.Ltd

Contact:+86-731-82197655

Address:No.649,Chezhan Rd.(N),Changsha,Hunan,China
Frapp's Chemical (NFTZ) Co.,Ltd

Contact:+86-576-86137892

Address:General Chamber of Commercial Building, 159 Wanchang Middle Road, Wenling, Zhejiang, China
Jiangsu Haian Petro chemical Plant

Contact:+86-513-88902723

Address:99, Changjiang West Road, Haian County, Jiangsu
Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Shanghai Longjin Metallic Material Co., Ltd.

website:http://www.shlongjin.cn/

Contact:021-56517503,56502257

Address:No.16, Lane 555, Chengyin Road, Shanghai

Relevant to this article

Ortho-benzoxylation of N-alkyl benzamides with aromatic acids catalyzed by ruthenium(II) complex

Doi:10.1002/chem.201304646
(2014)
Design and synthesis of 24-fluorinated bafilomycin analogue as an NMR probe with potent inhibitory activity to vacuolar-type ATPase

Doi:10.1246/cl.131099
(2014)
Synthesis, characterization and catalytic activity of dinuclear half-sandwich Ru(II), Rh(III) and Ir(III) complexes

Doi:10.1016/j.jorganchem.2014.04.024
(2014)
A facile synthesis of 2-(aminomethyl)purines

Doi:10.1055/s-1994-25699
(1994)
Microwave assisted tandem heck-sonogashira reactions of N,N-Di-Boc-protected 6-amino-5-iodo-2-methyl pyrimidin-4-ol in an efficient approach to functionalized pyrido[2,3-d]pyrimidines

Doi:10.1021/ol501459e
(2014)
Highly efficient deprotection of phenolic tetrahydropyranyl and methoxymethyl ethers and sequel cyclization to indanones using Sn(IV)Cl ₄ catalyst

Doi:10.1016/j.tetlet.2014.05.009
(2014)

Article Doi