Stereoselective Formation of Three Carbon-Carbon Bonds by Cascade Reaction with Enolate Anion: Synthesis of Tricyclo1,6>dodecane and Tricyclo3,8>undecane Derivatives

DOI: 10.1021/jo00099a034

Source and publish data:

Journal of Organic Chemistry p. 6008 - 6013 (1994)

Update date:2022-09-26

Topics: Synthesis Derivatives Cascade reaction Stereoselective

Authors:

Ihara, Masataka

Makita, Kei

Tokunaga, Yuji

Fukumoto, Keiichiro

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Article abstract of DOI:10.1021/jo00099a034

Reaction of 6-<5(E)-6-(methoxycarbonyl)hex-5-enyl>-2-cyclohexen-1-one (1) with LHMDS, followed by one-pot treatment with CH2O, resulted in a cascade Michael-Michael-aldol reaction, producing hydroxymethylated tricyclo<6.2.2.0^1,6>dodecane 3.The

Full text of DOI:10.1021/jo00099a034

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