Rhodium-Mediated Insertion of CF3-Substituted Carbenoid into O-H: An Efficient Method for the Synthesis of α-Trifluoromethylated Alkoxy- and Aryloxyacetic Acid Derivatives

Article abstract of DOI:10.1016/0040-4020(95)98698-H

CF3-substituted diazo compound 2 undergoes facile rhodium carbenoid mediated O-H insertion reaction with a variety of alcohols and phenols to afford the title compounds in good yield.Use of the title compounds as synthetic precursors for other fluorinated