Rhodium-Mediated Insertion of CF3-Substituted Carbenoid into O-H: An Efficient Method for the Synthesis of α-Trifluoromethylated Alkoxy- and Aryloxyacetic Acid Derivatives

DOI: 10.1016/0040-4020(95)98698-H

Source and publish data:

Tetrahedron p. 5011 - 5018 (1995)

Update date:2022-08-03

Topics:

Authors:

Shi, Guo-qiang

Cao, Zhi-yao

Cai, Wei-ling

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Article abstract of DOI:10.1016/0040-4020(95)98698-H

CF3-substituted diazo compound 2 undergoes facile rhodium carbenoid mediated O-H insertion reaction with a variety of alcohols and phenols to afford the title compounds in good yield.Use of the title compounds as synthetic precursors for other fluorinated

Full text of DOI:10.1016/0040-4020(95)98698-H

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