The synthesis of a hematoregulatory agent based on HP-5b containing an effective, achiral cystine replacement

Article abstract of DOI:10.1016/S0960-894X(96)00505-7

The cystine moiety of the novel hematoregulatory peptide HP-5b has been substituted with an achiral N,N'-bis(carboxymethyl)-1,4-diaminobutane unit. The resulting compound was also a potent hematoregulatory agent, suggesting that N,N'bis(carboxymethyl)-1,4-diaminobutane can function as an effective achiral cystine replacement in this molecular series.