Bioorganic and Medicinal Chemistry Letters p. 2709 - 2712 (1996)
Update date:2022-08-04
Topics:
LoCastro, Stephen M.
Heerding, Dirk A.
Bhatnagar, Pradip K.
King, Andrew
The cystine moiety of the novel hematoregulatory peptide HP-5b has been substituted with an achiral N,N'-bis(carboxymethyl)-1,4-diaminobutane unit. The resulting compound was also a potent hematoregulatory agent, suggesting that N,N'bis(carboxymethyl)-1,4-diaminobutane can function as an effective achiral cystine replacement in this molecular series.
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