Journal of the Chemical Society. Chemical communications p. 811 - 812 (1995)
Update date:2022-08-04
Topics:
Yoshida, Yukio
Sato, Yoshitaka
Okamoto, Sentaro
Sato, Fumie
A highly efficient and practical synthesis of enantiomerically pure benzoprostacyclins, chemically stable and therapeutically useful prostaglandin I2 analogues, is developed which includes an efficient preparation of 2-<3-bromo-2-(allyloxy)phenyl>-4-siloxycyclopent-2-en-1-one 3 in optically active form and the conjugate addition of ω side-chains onto 3 followed by cyclization to the key intermediate (1R,2R,3'S)-2-endo-siloxy-1-exo-(3'-siloxyalk-1-enyl)-3a,8b-cis-2,3,3a,8b-tetrahydro-1H-5-bromocyclopentabenzofuran 4.
View MoreJiangxi Global Natural Spice Co., Ltd.
website:https://www.jxhqxl.com/
Contact:+86-796-8106598
Address:No.89, Wenshan Road,South Industrial Park, Jishui County,Jiangxi Province
website:http://www.hanwayschem.com
Contact:+86-18502787239(whatsapp)-
Address:18-1-802, Green Garden, Jianghan District, Wuhan 430023, China
Nanjing Ruizhi Industry & Technologh Co.，Ltd.
Contact:+86-25-86808110
Address:441-4-A5,NO.12 Longzang Avenue,Yuhuatai District,210039,Nanjing
Contact:+86+21-58956006 15800617331
Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Anhui Qingyun Pharmaceutical and Chemical Co.,Ltd
Contact:+86-551-63633067
Address:Shuangfeng Road Hefei Anhui
Doi:10.1021/acs.jafc.7b05813
(2018)Doi:10.1002/hlca.19950780518
(1995)Doi:10.1021/jo00123a030
(1995)Doi:10.1021/bi00858a035
(1967)Doi:10.1002/chem.201801031
(2018)Doi:10.1111/j.1749-6632.1971.tb53187.x
(1971)
