Bioorganic and Medicinal Chemistry Letters p. 569 - 572 (1996)
Update date:2022-08-05
Topics:
Dupre, Brian
Bui, Huong
Scott, Ian L.
Market, Robert V.
Keller, Karin M.
Beck, Pamela J.
Kogan, Timothy P.
A novel class of biphenyl-based compounds were investigated for their ability to inhibit sialyl Lewis X (sLe(X) dependent binding of HL-60 cells to E- and P-selectin fusion proteins. Compounds (2b) and (2h) demonstrated improved binding as compared to both the natural ligand sLe(X) and a previously reported inhibitor TBC-265 (1, R = 3-CH2CO2H).
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