Synthesis and properties of N(α)-(tert-butyloxycarbonyl)peptide p- guanidinophenyl esters as trypsin substrates

DOI: 10.1248/cpb.43.2082

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2082 - 2087 (1995)

Update date:2022-08-04

Topics:

Authors:

Itoh Itoh

Sekizaki

Toyota Toyota

Tanizawa

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.43.2082

N(α)-(tert-Butyloxycarbonyl)peptide p-guanidinophenyl esters were synthesized by amidination of N(α)-(tert-butyloxycarbonyl)peptide p- aminophenyl esters with 1-[N,N'-bis(benzyloxycarbonyl)amidino]pyrazole, followed by deprotection by catalytic hydrogenation, in good total yields. These synthetic esters were characterized as specific substrates for trypsin, and kinetic parameters for the trypsin-catalyzed hydrolysis are presented.

Full text of DOI:10.1248/cpb.43.2082

NII-Electronic Library Service

Products guided by the article

Product name:(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionic acid 4-benzyloxycarbonylamino-phenyl ester

Cas No:174359-57-0

R&D Labs maybe for 174359-57-0

Anhui Xinyuan Technology Co.,Ltd

Contact:0086-559-3515800

Address:No.16 Zijin Rd, Circular Economic Zone, Huizhou District, Huangshan Anhui China
Beijing Mashi Fine Chemical Co.,Ltd.

Contact:+86-10-61271592

Address:Room 506, Section B, Kaichi Mansion, Industrial Development
Shanghai Cheerchem Co., Ltd.

Contact:86-21-50966856

Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
SHANXI XINTIANYUAN PHARMACEUTICAL CO., LTD.

website:http://www.tychemical.com

Contact:0086-358-3521713 3521715

Address:No. 1 Yintong Road, Shanxi Jiaocheng Economic Development Zone, Xiajiaying Town, Jiaocheng County, Lvliang City, Shanxi Province, China
JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China

Relevant to this article

Synthesis of Fischer carbene complex of iridium by C-H bond activation of methyl and cyclic ethers: Evidence for reversible α-hydrogen migration

Doi:10.1021/ja953437t
(1996)
Transfer technology III: The synthesis of bridged cyclic polyenes using a new retrosynthetic algorithm as a guide

Doi:10.1016/S0040-4039(00)97245-9
(1990)
Syntheses and Reactions of the Diethyl α-Alkynylmalonates Involving the Generation of Conjugated Allenyl Esters as the Latent Active Species: A New Approach to the Development of Cysteine Proteinase Inhibitors

Doi:10.1016/0040-4039(95)02284-8
(1996)
Bis-phosphites and bis-phosphinites based on distally-functionalised calix[4]arenes: Coordination chemistry and use in rhodium-catalysed, low-pressure olefin hydroformylation

Doi:10.1039/b419284b
(2005)
5-Exo-dig radical cyclization of enediynes: The first synthesis of tin-substituted benzofulvenes

Doi:10.1021/ol049122c
(2004)
Practical, stereoselective synthesis of palinavir, a potent HIV protease inhibitor

Doi:10.1021/jo9702655
(1997)

Article Doi