Synthesis and properties of N(α)-(tert-butyloxycarbonyl)peptide p- guanidinophenyl esters as trypsin substrates

DOI: 10.1248/cpb.43.2082

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2082 - 2087 (1995)

Update date:2022-08-04

Topics:

Authors:

Itoh Itoh

Sekizaki

Toyota Toyota

Tanizawa

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Article abstract of DOI:10.1248/cpb.43.2082

N(α)-(tert-Butyloxycarbonyl)peptide p-guanidinophenyl esters were synthesized by amidination of N(α)-(tert-butyloxycarbonyl)peptide p- aminophenyl esters with 1-[N,N'-bis(benzyloxycarbonyl)amidino]pyrazole, followed by deprotection by catalytic hydrogenation, in good total yields. These synthetic esters were characterized as specific substrates for trypsin, and kinetic parameters for the trypsin-catalyzed hydrolysis are presented.

Full text of DOI:10.1248/cpb.43.2082

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