Analogs of the β-turn of the cyclodepsipeptide didemnin B

Article abstract of DOI:10.1016/0040-4039(95)02160-4

Three side chain analogs of didemnin B were synthesized. All three analogs of the only conventional type II β-turn present in didemnin B differed in the functionality incorporated in the threonine residue. The cytotoxic activities of these analogs were evaluated, and one of them exhibited weak activity.