Synthesis of enantiomerically pure 1-(R)- and 1-(S)-hydroxymethyl-DTPA penta-t-butyl esters via chiral aminoalcohols

Article abstract of DOI:10.1080/00397919608004564

A convenient synthesis of enantiomerically enriched 1-hydroxymethyl-DTPA (diethylenetriamine pentaacetic acid) penta-t-butyl esters 3 has been achieved for the preparation of chiral synthones of new paramagnetic gadolinium complexes.

Full text of DOI:10.1080/00397919608004564

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Synthetic Communications: An
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Organic Chemistry
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Synthesis of Enantiomerically
Pure 1-(R)- and 1-(S)-
Hydroxymethyl-Dtpa Penta-
t-Butyl Esters Via Chiral
Aminoalcohols
Hironao Sajiki a b , Karen Y. Ong a , Samuel T. Nadler
a c , Heather E. Wages a & Thomas J. McMurry a
a Metasyn, Inc. , 71 Rogers St., Cambridge,
Massachusetts, 02142, USA
b Laboratory of Medicinal Chemistry , Gifu
Pharmaceutical University , Gifu, 502, Japan Fax:
c University of Wisconsin Medical School , Madison,
Wisconsin, 53705
Published online: 23 Aug 2006.
To cite this article: Hironao Sajiki , Karen Y. Ong , Samuel T. Nadler , Heather E.
Wages & Thomas J. McMurry (1996) Synthesis of Enantiomerically Pure 1-(R)- and
1-(S)-Hydroxymethyl-Dtpa Penta-t-Butyl Esters Via Chiral Aminoalcohols, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 26:13, 2511-2522, DOI: 10.1080/00397919608004564
To link to this article: http://dx.doi.org/10.1080/00397919608004564
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