Bioorganic and medicinal chemistry p. 2055 - 2069 (1996)
Update date:2022-08-03
Topics:
Qian
Moris-Varas
Fitzgerald
Wong
C2-Symmetrical tetrahydroxyazepanes were synthesized as inhibitors for glycosidases. Tetrahydroxyazepane 1 is a non-specific inhibitor of various glycosidases, while compounds 2, 3 and 4 specifically inhibit beta-N-acetylglucosaminidase, beta-glucosidase, and alpha-fucosidase, respectively, with Ki in the micromolar range. Compound 1 is not an inhibitor of HIV/FIV proteases, but its 3,6-difluorobenzyl derivatives are moderate inhibitors of both enzymes.
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Doi:10.1107/S0108270196001527
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(1996)Doi:10.1016/S0022-328X(96)06142-6
(1996)Doi:10.1016/0040-4020(96)00261-X
(1996)
