Replacement of the phosphodiester linkage in oligonucleotides by an acetylenic bond: Comparison between carbon-, sulfur-, and oxygen-containing analogs

DOI: 10.1016/0040-4039(96)01164-1

Source and publish data:

Tetrahedron Letters p. 5511 - 5514 (1996)

Update date:2022-08-03

Topics:

Authors:

Wendeborn, Sebastian

Jouanno, Chantal

Wolf, Romain M.

De Mesmaeker, Alain

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Article abstract of DOI:10.1016/0040-4039(96)01164-1

Four acetylene-containing dimers were synthesized and incorporated into oligonucleotides. The hybridization properties of the modified oligonucleotides to RNA complements and their conformational analysis are reported.

Full text of DOI:10.1016/0040-4039(96)01164-1

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