Replacement of the phosphodiester linkage in oligonucleotides by an acetylenic bond: Comparison between carbon-, sulfur-, and oxygen-containing analogs

Article abstract of DOI:10.1016/0040-4039(96)01164-1

Four acetylene-containing dimers were synthesized and incorporated into oligonucleotides. The hybridization properties of the modified oligonucleotides to RNA complements and their conformational analysis are reported.