Synthesis of enantiopure α,ω-diamino dicarboxylates and azabicycloalkane amino acids by Claisen condensation of α-[N-(phenylfluorenyl)amino] dicarboxylates

DOI: 10.1021/jo00100a008

Source and publish data:

Journal of Organic Chemistry p. 6147 - 6149 (1994)

Update date:2022-07-30

Topics:

Authors:

Lombart Lombart

Lubell Lubell

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00100a008

Enantiomerically pure (3S,6S,9S)-2-oxo-3-(N-BOC-amino)-1-azabicyclo[4.3.0]nonane-9-carboxyli c acid ((3S,6S,9S)-1) was prepared in 39% overall yield from α-tert-butyl γ-methyl N-(9-(9-phenylfluorenyl))glutamate (5) using a Claisen condensation/reductive amination/lactam cyclization sequence.

Full text of DOI:10.1021/jo00100a008

Products guided by the article

Product name:1,3,7-Heptanetricarboxylic acid, 4-oxo-1,7-bis[(9-phenyl-9H-fluoren-9-yl)amino]-, 1,7-bis(1,1-dimethylethyl) 3-methyl ester, (1S,7S)-

Cas No:185121-26-0

R&D Labs maybe for 185121-26-0

shanghai jinshan pharmaceutical Co.,Ltd

Contact:021-57363011，13681638167

Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan
Suzhou JMS Chemical Co., Ltd.

Contact:+86-15995924277

Address:WuZhongOu suzhou new south road 89
Chiral Quest (Suzhou) Company Ltd

website:http://www.chiralquest.com

Contact:+86-0512-62956066

Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park
KAIYUAN CHEMICAL COMPANY LIMITED.

website:http://www.kaiyuanchem.com

Contact:+86-22-59891255/66/77

Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.

Relevant to this article

Bifunctional carriers of alkali-metal enolates: The use of zirconium meso-octaethylporphyrinogen in aldol condensation reactions

Doi:10.1021/om9609325
(1997)
Efficient Synthesis of Diastereomerically Pure Vicinal Diamines: meso-2,3-Bis(methylamino)butane and cis-1,2-Bis(methylamino)cycloalkanes

Doi:10.1021/jo961972l
(1997)
Important consequences for gas chromatographic analysis of the Sonogashira cross-coupling reaction

Doi:10.1016/j.tetlet.2004.03.060
(2004)
Stereocontrolled synthesis of 2-amino-2-deoxy-α-D-C-glycopyranosides by radical cyclization reactions

Doi:10.1016/S0040-4039(96)02153-3
(1996)
Synthesis, pharmacology and pharmacokinetics of 3-(4-Arylpiperazin-1-ylalkyl)-uracils as uroselective α_1A-antagonists

Doi:10.1016/S0960-894X(03)00305-6
(2003)
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase

Doi:10.1021/ja0753290
(2007)

Article Doi