Preparation of triazamacrocycles containing only secondary amine functions using both tosyl and BOC protecting groups

Article abstract of DOI:10.1002/jhet.5570330672

1,8,15-Triazacycloheneicosane (1); 1,9,17-triazacyclotetracosane (2) and 1,10,19-triazacycloheptacosane (3) were prepared by treating the appropriate N,N-bis(ω-bromoalkyl)toluenesulfonamide 8-10 with the appropriate N,N'-ditosyl-α,ω-diaminoalkane 11-13 in