Synthesis of (2'S,3'S)-9-(4'-phosphono-4',4'-difluoromethanobutyl)guanine and its enantiomer. Evaluation of the inhibitory activity for purine nucleoside phosphorylase

DOI: 10.1016/S0040-4020(97)00704-7

Source and publish data:

Tetrahedron p. 11297 - 11306 (1997)

Update date:2022-08-03

Topics:

Authors:

Yokomatsu, Tsutomu

Sato, Mutsumi

Abe, Hiroshi

Suemune, Kenji

Matsumoto, Keita

Kihara, Taro

Soeda, Shinji

Shimeno, Hiroshi

Shibuya, Shiroshi

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(97)00704-7

Conformationally constrained analogues 2a and ent-2a of 9-(difluorophosphonophenyl) guanines 1, a multi-substrate analogue inhibitor of PNP, were prepared from optically active trans-1-(diethoxyphosphinyl)difluromethyl-2-hydroxymethylcyclopropanes (+)-6 a

Full text of DOI:10.1016/S0040-4020(97)00704-7

Products guided by the article

Product name:(1S,2S)-1-(diethoxyphosphinyldifluoro)methyl-2-(4'-toluenesulfonyl)oxymethylcyclopropane

Cas No:194546-53-7

R&D Labs maybe for 194546-53-7

Shandong Shouguang Songchuan Industrial Additives Co.,Ltd

Contact:+86-536-8566856

Address:Shouguang,Shandong,China
Shanghai Massive Chemical Technology Co., Ltd.

website:http://www.massivechem.com/

Contact:+86 21 34943721

Address:Room 435, 4th floor, Building 9, No. 2568 Gudai Road,Minhang District, Shanghai,
Shanghai Cheerchem Co., Ltd.

Contact:86-21-50966856

Address:Building 5,300 Chuanzhan Road,Pudong New District,Shanghai
Wuhan Chemchemical Co., Ltd.(expird)

Contact:15973022782

Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Suzhou BEC Fine Chemicals Co., Ltd.

website:http://www.bek.com.cn

Contact:0512-68095917　 18913193865

Address:6, Jin Shan Road, Suzhou New District, 215011 China Suzhou Nations Pharmaceutical Innovation Center Inside

Relevant to this article

Pseudoelement compounds. XI. [1]: Investigations on the coordination behaviour of cyanamidonitrate [NO₂NCN]^-

Doi:10.1002/zaac.19976230821
(1997)
Intermolecular hydrophosphination of alkynes and related carbon-carbon multiple bonds catalyzed by organoytterbiums

Doi:10.1021/jo030163g
(2003)
Synthesis of model tricyclic C-O-D-O-E-F-O-G ring of teicoplanin

Doi:10.1016/S0040-4039(97)01280-X
(1997)
Rhizobial saccharides part 3. Unexpected α-selective glycosylation during synthesis of pyruvated tetrasaccharide fragments related to exopolysaccharides of rhizobium leguminosarum

Doi:10.1080/07328309708006537
(1997)
Synthesis of β-Alkoxy Ketones and α′-Functionalized β-Alkoxy Ketones Utilizing Benzotriazole-Stabilized Acyl Anion Synthons

Doi:10.1021/jo971630v
(1998)
Double insertion of carbon bisulfide into Pb-S bonds of lead(II) bis(arenethiolate): Synthesis and crystal structure of lead(II) bis(aryl trithiocarbonate)

Doi:10.1021/om970861p
(1998)

Article Doi