Synthesis of (2'S,3'S)-9-(4'-phosphono-4',4'-difluoromethanobutyl)guanine and its enantiomer. Evaluation of the inhibitory activity for purine nucleoside phosphorylase

DOI: 10.1016/S0040-4020(97)00704-7

Source and publish data:

Tetrahedron p. 11297 - 11306 (1997)

Update date:2022-08-03

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Authors:

Yokomatsu, Tsutomu

Sato, Mutsumi

Abe, Hiroshi

Suemune, Kenji

Matsumoto, Keita

Kihara, Taro

Soeda, Shinji

Shimeno, Hiroshi

Shibuya, Shiroshi

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Article abstract of DOI:10.1016/S0040-4020(97)00704-7

Conformationally constrained analogues 2a and ent-2a of 9-(difluorophosphonophenyl) guanines 1, a multi-substrate analogue inhibitor of PNP, were prepared from optically active trans-1-(diethoxyphosphinyl)difluromethyl-2-hydroxymethylcyclopropanes (+)-6 a

Full text of DOI:10.1016/S0040-4020(97)00704-7

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