Bioorganic and Medicinal Chemistry p. 1489 - 1495 (1997)
Update date:2022-08-03
Topics:
Ohno, Nobuhiro
Fukamiya, Narihiko
Okano, Masayoshi
Tagahara, Kiyoshi
Lee, Kuo-Hsiung
The C-15 senecioyl side chain of brusatol was interchanged with fluorinated acyl groups, and the C-3 hydroxy group of bruceolide was esterified with fluorinated acyl chlorides. These fluorinated quassinoids 11, 12, 13, and 17 showed significant cytotoxic activity against eight human cancer cell lines including small and non-small cell lung, colon, CNS, ovarian and renal cancers, leukemia, and melanoma with 17 being about 100 times more potent than 11, 12, and 13. The activity of 17 was similar to that of bruceantin (1) in this in vitro cell line panel.
View MoreShanghai Coupling Pharmaceutical R&D Co., Ltd.(expird)
Contact:+86 021 50106671
Address:403 Room No.4 Buiding, No. 526 Ruiqing Road, Shanghai Zhangjiang Hi-Tech Park
Suzhou Lixin Pharmaceutical Co., Ltd.
Contact:86-512-88169812
Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Contact:0086 533 2282832
Address:Zibo，Shandong
Guangzhou Puho Pharmaceutical Technology Co. Ltd.
Contact:86-20-29848035/29848075
Address:No.166, Chaoyang East Road, Panyu District, Guangzhou City, Guangdong Province
Lanling Hongchuang Flame Retardant Co., Ltd.
Contact:+86-531-68858132
Address:East Huafeichang Road, Cangshan County, Linyi, Shandong, China (Mainland)
Doi:10.1016/j.carbpol.2018.07.089
(2018)Doi:10.1021/jo0258406
(2002)Doi:10.1002/jlcr.2580150153
(1978)Doi:10.1016/S0008-6215(00)86061-9
(1979)Doi:10.1016/S0040-4039(02)00067-9
(2002)Doi:10.1016/j.ejmech.2020.112411
(2020)
