Generation and intramolecular cyclization of difluoroalkyl radicals via single electron transfer from the benzeneselenolate anion: Synthesis of α,α-difluoro-γ-lactams

Article abstract of DOI:10.1016/S0040-4039(97)10073-9

Several α,α-difluoro-γ-lactams (2) were prepared by radical cyclization of amides (1) which were initiated by a single transfer(SET) process from the benzenesclenolate anion. Deselenation of these lactams (2) gave the corresponding α,α-difluoro-β-exomethylene lactams (8).