Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

DOI: 10.1016/S0960-894X(98)00163-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1019 - 1022 (1998)

Update date:2022-08-05

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Authors:

Sasaki, Shigeki

Hashimoto, Tomohiro

Obana, Norihiro

Yasuda, Hideyo

Uehara, Yoshimasa

Maeda, Minoru

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Article abstract of DOI:10.1016/S0960-894X(98)00163-2

New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.

Full text of DOI:10.1016/S0960-894X(98)00163-2

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