Design of new inhibitors for cdc2 kinase based on a multiple pseudosubstrate structure

DOI: 10.1016/S0960-894X(98)00163-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1019 - 1022 (1998)

Update date:2022-08-05

Topics:

Authors:

Sasaki, Shigeki

Hashimoto, Tomohiro

Obana, Norihiro

Yasuda, Hideyo

Uehara, Yoshimasa

Maeda, Minoru

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(98)00163-2

New inhibitors have been designed for cdc2 kinase based on a multiple pseudosubstrate structure. The new inhibitors have three different structural components: 3,4-bis(indol-3-yl)maleimide, Ac-Cys-(Ser)-Pro-Lys-Lys-NHMe, and ethyloxy group between the two components. Inhibitory activities toward cdc2 and other protein kinases were investigated, and the compound (21) with Ac- Cys-Pro-Lys-Lys-NHMe connected with the triethylene glycol spacer exhibited the most potent inhibition with relatively high selectivity.

Full text of DOI:10.1016/S0960-894X(98)00163-2

Products guided by the article

Product name:1-Benzyl-3-(1H-indol-3-yl)-4-{1-[2-(2-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy}-ethoxy)-ethyl]-1H-indol-3-yl}-pyrrole-2,5-dione

Cas No:208777-05-3

R&D Labs maybe for 208777-05-3

SHANGHAI RC CHEMICALS CO.,LTD.

website:http://www.rcc.net.cn

Contact:+86-21-50322175

Address:Rm1415 Yinqiao Masion No.58 Jinxin Road Pudong Shanghai China
Nanjing Chemlin Chemical Co., Ltd.

website:http://www.echemlin.cn

Contact:+86-25-83697070

Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China
Landz International Company Ltd.

Contact:0086-21-58891610

Address:985 Dongfang Road, Pudong, Shanghai 200122 China
Ningbo J&S Botanics Inc.

Contact:86-574-26865651

Address:529 YuanBaoShan Road, Beilun District
Shanghai Apeptide Co., Ltd.

website:http://www.apeptides.com/en/

Contact:+86-21-60871011

Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai

Relevant to this article

Variable coordination modes of NO₂^- in a series of Ag(I) complexes containing triorganophosphines, -arsines, and -stibines. Syntheses, spectroscopic characterization (IR, ¹H and ³¹P NMR, electrospray ionization mass), and structures of [AgNO₂(R₃E)_x] adducts (E = P, As, Sb, x = 1-3)

Doi:10.1021/ic020375g
(2002)
Electrochemical synthesis of metal (II) complexes of Schiff base 2-tosylamino (2′-pyridyl)aniline: The crystal structure of bis-[2-tosylamino(2′-pyridyl)anilinato]cobalt(II)

Doi:10.1016/S0277-5387(97)00376-8
(1998)
Doi:10.1016/S0040-4039(00)72793-6
(1968)
Terminal 1-halo and 1-pseudohalo-1-alkynes via Bis(trimethylsilyl)peroxide (BTMSPO) promoted Umpolung transfer of halides and pseudohalides

Doi:10.1016/S0040-4039(00)71266-4
(1991)
Doi:10.1039/j39680002947
(1968)
A chiral hydrazone derived from D-glyceraldehyde: A convenient starting material for the stereoselective synthesis of α-hydrazino acids

Doi:10.1016/S0957-4166(97)00128-6
(1997)

Article Doi