New podophyllotoxin derivatives as potential anticancer agents: Synthesis and cytotoxicity of 4β-O-propenylpodophyllotoxin ethers

Article abstract of DOI:10.1080/00397919908085779

4β-O-Propenylethers of podophyllotoxin 3a-e were prepared from 4- chloro-4-deoxypodophyllotoxin 2 and allylic alcohols. Cytotoxicity of these compounds against KB cells is reported.

Full text of DOI:10.1080/00397919908085779

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Synthetic Communications: An
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Organic Chemistry
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New Podophyllotoxin
Derivatives as Potential
Anticancer Agents: Synthesis
and Cytotoxicity of 4β-O-
Propenylpodophyllotoxin
Ethers
Yadagiri Bathini a , Andrew Scholte a , Sean Kelly a
R. G. Micetich a & Moshen Daneshtalab b
,
a Synphar laboratories Inc. #2 , 4290-91A Street,
Edmonton, Alberta, Canada , T6E 5V2
b Faculty of Pharmacy and Pharmaceutical Sciences,
University of Alberta , Edmonton, Alberta, Canada ,
T6G 2N8
Published online: 17 Sep 2007.
To cite this article: Yadagiri Bathini , Andrew Scholte , Sean Kelly , R. G. Micetich &
Moshen Daneshtalab (1999) New Podophyllotoxin Derivatives as Potential Anticancer
Agents: Synthesis and Cytotoxicity of 4β-O-Propenylpodophyllotoxin Ethers, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 29:3, 379-385, DOI: 10.1080/00397919908085779
To link to this article: http://dx.doi.org/10.1080/00397919908085779
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