Bioorganic and Medicinal Chemistry Letters p. 2699 - 2704 (1999)
Update date:2022-08-02
Topics:
Ruel, Rejean
Lacombe, Patrick
Abramovitz, Mark
Godbout, Claude
Lamontagne, Sonia
Rochette, Chantal
Sawyer, Nicole
Stocco, Rino
Tremblay, Nathalie M.
Metters, Kathleen M.
Labelle, Marc
A new class of potent and selective ligands for the human EP1 prostanoid receptor is described. SAR studies reported herein allowed the identification of several potent dibenzazocinones bearing an acylsulfonamide side chain. The binding affinity of these compounds on all eight human prostanoid receptors is reported.
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